EIF4E3

Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene.[5]

EIF4E3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4E3, eIF-4E3, eIF4E-3, eukaryotic translation initiation factor 4E family member 3
External IDsOMIM: 609896 MGI: 1914142 HomoloGene: 41652 GeneCards: EIF4E3
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p13Start71,675,414 bp[1]
End71,754,773 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

317649

66892

Ensembl

ENSG00000163412

ENSMUSG00000093661

UniProt

Q8N5X7

Q9DBB5

RefSeq (mRNA)

NM_001134649
NM_001134650
NM_001134651
NM_001282886
NM_173359

NM_025829

RefSeq (protein)

NP_001128121
NP_001128122
NP_001128123
NP_001269815
NP_775495

NP_080105

Location (UCSC)Chr 3: 71.68 – 71.75 MbChr 6: 99.63 – 99.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.[5][6]

Model organisms

Model organisms have been used in the study of EIF4E3 function. A conditional knockout mouse line, called Eif4e3tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty four tests were carried out on mutant mice but no significant abnormalities were observed.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000163412 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000093661 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Eukaryotic translation initiation factor 4E family member 3". Retrieved 2011-09-28.
  6. Joshi, B.; Cameron, A.; Jagus, R. (2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry. 271 (11): 2189–2203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
  7. "Salmonella infection data for Eif4e3". Wellcome Trust Sanger Institute.
  8. "Citrobacter infection data for Eif4e3". Wellcome Trust Sanger Institute.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248): 0. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. "International Knockout Mouse Consortium".
  12. "Mouse Genome Informatics".
  13. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  • Overview of all the structural information available in the PDB for UniProt: Q9DBB5 (Mouse Eukaryotic translation initiation factor 4E type 3) at the PDBe-KB.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.