FBXL7

FBXL7
Identifiers
Aliases	FBXL7, FBL6, FBL7, F-box and leucine-rich repeat protein 7, F-box and leucine rich repeat protein 7
External IDs	OMIM: 605656 MGI: 3052506 HomoloGene: 69121 GeneCards: FBXL7
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	15,939,795 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	26,895,580 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• ubiquitin-protein transferase activity;
Cellular component	• cytoplasm; • ubiquitin ligase complex; • microtubule organizing center; • centrosome; • SCF ubiquitin ligase complex; • cytoskeleton; • cytosol;
Biological process	• cell division; • cell cycle; • cellular proliferation; • G2/M transition of mitotic cell cycle; • protein ubiquitination; • ubiquitin-dependent protein catabolic process; • protein polyubiquitination; • SCF complex assembly; • negative regulation of G2/M transition of mitotic cell cycle; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • GO:0007067 mitotic cell cycle; • post-translational modification;
	Sources:Amigo / QuickGO
Orthologs
	23194
	448987
	ENSG00000183580
	ENSMUSG00000043556
	Q9UJT9
	Q5BJ29
	NM_001278317; NM_012304
	NM_176959
	NP_001265246; NP_036436
	NP_795933
	Wikidata
View/Edit Human	View/Edit Mouse

F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.[5][6][7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats.[7]

References

GRCh38: Ensembl release 89: ENSG00000183580 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000043556 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
"Entrez Gene: FBXL7 F-box and leucine-rich repeat protein 7".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (2001). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics. 67 (1): 40–7. doi:10.1006/geno.2000.6211. PMID 10945468.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Watanabe N, Arai H, Nishihara Y, et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. doi:10.1073/pnas.0307700101. PMC 384762. PMID 15070733.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183580 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043556 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[pmid10531035-6] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.

[entrez-7] "Entrez Gene: FBXL7 F-box and leucine-rich repeat protein 7".

FBXL7

References

Further reading