Ferredoxin:protochlorophyllide reductase (ATP-dependent)

Ferredoxin:protochlorophyllide reductase (ATP-dependent) (EC 1.3.7.7), light-independent protochlorophyllide reductase) is an enzyme with systematic name ATP-dependent ferredoxin:protochlorophyllide-a 7,8-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

protochlorophyllide + reduced ferredoxin + 2 ATP + 2 H2O chlorophyllide a + oxidized ferredoxin + 2 ADP + 2 phosphate
  • Structure of the substrate and product of the enzyme
  • Protochlorophyllide
  • Chlorophyllide a
Ferredoxin:protochlorophyllide reductase (ATP-dependent)
Identifiers
EC number1.3.7.7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

It can alternatively take as its substrate the compound with a second vinyl group (instead of an ethyl group) in the structure, in which case the reaction is

3,8-divinylprotochlorophyllide + reduced ferredoxin + 2 ATP + 2 H2O 3,8-divinylchlorophyllide a + oxidized ferredoxin + 2 ADP + 2 phosphate

This enzyme is present in photosynthetic bacteria, cyanobacteria, green algae and gymnosperms and is part of the biosynthetic pathway to chlorophylls.[4][5]

See also

References
  1. Fujita Y, Matsumoto H, Takahashi Y, Matsubara H (March 1993). "Identification of a nifDK-like gene (ORF467) involved in the biosynthesis of chlorophyll in the cyanobacterium Plectonema boryanum". Plant & Cell Physiology. 34 (2): 305–14. PMID 8199775.
  2. Nomata J, Ogawa T, Kitashima M, Inoue K, Fujita Y (April 2008). "NB-protein (BchN-BchB) of dark-operative protochlorophyllide reductase is the catalytic component containing oxygen-tolerant Fe-S clusters". FEBS Letters. 582 (9): 1346–50. doi:10.1016/j.febslet.2008.03.018. PMID 18358835.
  3. Muraki N, Nomata J, Ebata K, Mizoguchi T, Shiba T, Tamiaki H, et al. (May 2010). "X-ray crystal structure of the light-independent protochlorophyllide reductase". Nature. 465 (7294): 110–4. doi:10.1038/nature08950. PMID 20400946.
  4. Willows RD (June 2003). "Biosynthesis of chlorophylls from protoporphyrin IX". Natural Product Reports. 20 (3): 327–41. doi:10.1039/B110549N. PMID 12828371.
  5. Bollivar DW (November 2006). "Recent advances in chlorophyll biosynthesis". Photosynthesis Research. 90 (2): 173–94. doi:10.1007/s11120-006-9076-6. PMID 17370354.
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