Galactonolactone dehydrogenase

L-galactonolactone dehydrogenase (EC 1.3.2.3, galactonolactone dehydrogenase, L-galactono-gamma-lactone dehydrogenase, L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase, GLDHase, GLDase) is an enzyme with systematic name L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(1) L-galactono-1,4-lactone + 2 ferricytochrome c L-ascorbate + 2 ferrocytochrome c + 2 H+
(2) L-ascorbate + 2 ferricytochrome c L-dehydroascorbate + 2 ferrocytochrome c + 2 H+ (spontaneous)
L-galactonolactone dehydrogenase
Identifiers
EC number1.3.2.3
CAS number2603847
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme catalyses the final step in the biosynthesis of L-ascorbic acid in plants and other photosynthetic eukaryotes.[6]

References
  1. Mapson, L.W.; Breslow, E. (1957). "Properties of partially purified L-galactono-γ-lactone dehydrogenase". Biochem. J. 65: 29.
  2. Mapson LW, Isherwood FA, Chen YT (January 1954). "Biological synthesis of L-ascorbic acid: the conversion of L-galactono-gamma-lactone into L-ascorbic acid by plant mitochondria". The Biochemical Journal. 56 (1): 21–8. doi:10.1042/bj0560021. PMC 1269564. PMID 13126087.
  3. Isherwood FA, Chen YT, Mapson LW (January 1954). "Synthesis of L-ascorbic acid in plants and animals". The Biochemical Journal. 56 (1): 1–15. doi:10.1042/bj0560001. PMC 1269562. PMID 13126085.
  4. Oba K, Ishikawa S, Nishikawa M, Mizuno H, Yamamoto T (January 1995). "Purification and properties of L-galactono-gamma-lactone dehydrogenase, a key enzyme for ascorbic acid biosynthesis, from sweet potato roots". Journal of Biochemistry. 117 (1): 120–4. doi:10.1093/oxfordjournals.jbchem.a124697. PMID 7775377.
  5. Ostergaard J, Persiau G, Davey MW, Bauw G, Van Montagu M (November 1997). "Isolation of a cDNA coding for L-galactono-gamma-lactone dehydrogenase, an enzyme involved in the biosynthesis of ascorbic acid in plants. Purification, characterization, cDNA cloning, and expression in yeast". The Journal of Biological Chemistry. 272 (48): 30009–16. doi:10.1074/jbc.272.48.30009. PMID 9374475.
  6. Wheeler G, Ishikawa T, Pornsaksit V, Smirnoff N (March 2015). "Evolution of alternative biosynthetic pathways for vitamin C following plastid acquisition in photosynthetic eukaryotes". eLife. 4. doi:10.7554/eLife.06369. PMC 4396506. PMID 25768426.
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