Glidant

A glidant is a substance that is added to a powder to improve its flowability. A glidant will only work at a certain range of concentrations. Above a certain concentration, the glidant will in fact function to inhibit flowability.

In tablet manufacture, glidants are usually added just prior to compression.

Examples

Examples of glidants include ascorbyl palmitate[1], calcium palmitate[2], magnesium stearate, fumed silica (colloidal silicon dioxide), starch and talc.[3]

Mechanism of action

A glidant's effect is due to the counter-action of factors that cause poor flowability of powders. For instance, correcting surface irregularity, reducing interparticular friction and decreasing surface charge. The result is a decrease in the angle of repose which is an indication of an enhanced powder's flowability

References
  1. , "Use of ascorbyl palmitate and ascorbyl stearate as glidant for tablets", issued 2012-06-27
  2. "Vitamin & Supplement Recommendations for Your Health Concerns - Swanson®". www.swansonvitamins.com. Retrieved 2021-02-05.
  3. "SMI: Talc as a Glidant & Lubricant". 2012 Specialty Minerals Inc. Retrieved 19 March 2014.


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