Glutamate-5-semialdehyde

Glutamate-5-semialdehyde
Names
	IUPAC name (2S)-2-Amino-5-oxopentanoic acid
	Other names L-Glutamate gamma-semialdehyde; gamma-Glutamyl semialdehyde
Identifiers
CAS Number	2886-91-1;
3D model (JSmol)	Interactive image;
PubChem CID	193305;
	InChI InChI=1S/C5H9NO3/c6-4(5(8)9)2-1-3-7/h3-4H,1-2,6H2,(H,8,9)/t4-/m0/s1 Key: KABXUUFDPUOJMW-BYPYZUCNSA-N;
	SMILES C(C[C@@H](C(=O)O)N)C=O;
Properties
Chemical formula	C5H9NO3
Molar mass	131.131 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Glutamate-5-semialdehyde is a non-proteinogenic amino acid involved in the biosynthesis of proline and arginine (via ornithine), as well as in the biosynthesis of antibiotics, such as carbapenems. It is synthesized by the reduction of glutamyl-5-phosphate by glutamate-5-semialdehyde dehydrogenase.

References

Baich A (1971). "The biosynthesis of proline in Escherichia coli: phosphate-dependent glutamate -semialdehyde dehydrogenase (NADP), the second enzyme in the pathway". Biochim. Biophys. Acta. 244 (1): 129–34. doi:10.1016/0304-4165(71)90129-2. PMID 4399189.

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Glutamate-5-semialdehyde

See also

References