Gram domain-containing 2A

GRAMD2A
Identifiers
Aliases	GRAMD2A, GRAMD2, GRAM domain containing 2A
External IDs	MGI: 3528937 HomoloGene: 52791 GeneCards: GRAMD2A
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	72,197,787 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	59,718,874 bp[2]
Gene ontology
Molecular function	• phosphatidylinositol-4,5-bisphosphate binding; • phosphatidylinositol binding; • lipid binding;
Cellular component	• membrane; • integral component of membrane; • intrinsic component of endoplasmic reticulum membrane; • extrinsic component of cytoplasmic side of plasma membrane; • organelle membrane contact site; • endoplasmic reticulum; • endoplasmic reticulum membrane; • cell membrane;
Biological process	• endoplasmic reticulum-plasma membrane tethering; • regulation of store-operated calcium entry;
	Sources:Amigo / QuickGO
Orthologs
	196996
	546134
	ENSG00000175318
	ENSMUSG00000074259
	Q8IUY3
	Q3V3G7
	NM_001012642
	NM_001033498; NM_001357686; NM_001379375; NM_001379376; NM_001379377
	NP_001012660
	NP_001028670; NP_001344615; NP_001366304; NP_001366305; NP_001366306
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain-containing 2A protein (GRAMD2A; formerly GRAMD2) is a protein encoded by the GRAMD2A gene.[5] Like GRAMD2B, the protein consists of a GRAM domain and a transmembrane domain that anchors it to the endoplasmic reticulum.[6][7]

GRAMD2A is a mammalian representative of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.[7] It has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2B. Unlike LAM and its paralogs except GRAMD2B, GRAMD2A lacks a VASt domain.

The protein localizes to sites where membranes from different organelles are in close apposition.[7] There, it tethers the endoplasmic reticulum to the plasma membrane through its GRAM domain binding phosphatidylinositol 4,5-bisphosphate in the plasma membrane at sites enriched for the phospholipid.[7] The protein ensures proper stromal interaction molecule 1 (STIM1) recruitment to these sites of membrane contact as part of the store-operated calcium entry pathway – a component of intracellular calcium homeostasis.[7]

References

GRCh38: Ensembl release 89: ENSG00000175318 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000074259 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"GRAMD2A GRAM domain containing 2A [ Homo sapiens (human) ]". Retrieved March 7, 2020.
"RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.
Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175318 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074259 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "GRAMD2A GRAM domain containing 2A [ Homo sapiens (human) ]". Retrieved March 7, 2020.

[6] "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.

[pmid29469807-7] Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.