HAT1

Histone acetyltransferase 1, also known as HAT1, is an enzyme that, in humans, is encoded by the HAT1 gene.[5][6]

HAT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHAT1, KAT1, histone acetyltransferase 1
External IDsOMIM: 603053 MGI: 96013 HomoloGene: 2701 GeneCards: HAT1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q31.1Start171,922,448 bp[1]
End171,983,686 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8520

107435

Ensembl

ENSG00000128708

ENSMUSG00000027018

UniProt

O14929

Q8BY71

RefSeq (mRNA)

NM_001033085
NM_003642

NM_026115

RefSeq (protein)

NP_003633

NP_080391

Location (UCSC)Chr 2: 171.92 – 171.98 MbChr 2: 71.39 – 71.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are, in turn, imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, in particular, of histone H4, plays an important role in replication-dependent chromatin assembly. To be specific, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and, to a lesser degree, histone H2A at lysine 5.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000128708 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027018 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Verreault A, Kaufman PD, Kobayashi R, Stillman B (1998). "Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase". Curr. Biol. 8 (2): 96–108. doi:10.1016/S0960-9822(98)70040-5. PMID 9427644. S2CID 201273.
  6. "Entrez Gene: histone acetyltransferase 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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