HEPBS

HEPBS (N-(2-Hydroxyethyl)piperazine-N'-(4-butanesulfonic acid)) is a zwitterionic organic chemical buffering agent; one of Good's buffers. HEPBS and HEPES have very similar structures and properties, HEPBS also having an acidity (pKa) in the physiological range (7.6-9.0 useful range). This makes it possible to use it for cell culture work.

HEPBS 1H NMR spectrum.
HEPBS
Names
IUPAC name
N-(2-Hydroxyethyl)piperazine-N'-(4-butanesulfonic acid)[1][2][3]
Other names
HEPBS
Identifiers
3D model (JSmol)
Properties
C10H22N2O4S
Molar mass 266.356 g/mol
Appearance White crystalline powder
Density 1.25 g/cm3 (predicted)
Melting point 211–216 °C (412–421 °F; 484–489 K)
Acidity (pKa) 8.3
Hazards
Main hazards Irritant
GHS Signal word Warning
H315, H319, H335
P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405, P501
Flash point Non-flammable
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References

  1. "Compound Summary for CID 9965191". PubChem. 2006-10-25.
  2. "HEPBS, 99% (HPLC)". AKSci. 2017-07-23.
  3. "HEPBS (CAS 161308-36-7)". Santa Cruz Biotechnology.
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