HERPUD1

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein is a protein that in humans is encoded by the HERPUD1 gene.[5][6][7]

HERPUD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHERPUD1, HERP, Mif1, SUP, homocysteine inducible ER protein with ubiquitin like domain 1
External IDsOMIM: 608070 MGI: 1927406 HomoloGene: 40973 GeneCards: HERPUD1
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q13Start56,932,142 bp[1]
End56,944,864 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9709

64209

Ensembl

ENSG00000051108

ENSMUSG00000031770

UniProt

Q15011

Q9JJK5

RefSeq (mRNA)

NM_001010989
NM_001010990
NM_001272103
NM_014685

NM_022331
NM_001357205

RefSeq (protein)

NP_001010989
NP_001259032
NP_055500
NP_001259032.1

NP_071726
NP_001344134

Location (UCSC)Chr 16: 56.93 – 56.94 MbChr 8: 94.39 – 94.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.[7]

Interactions

HERPUD1 has been shown to interact with UBQLN1[8] and UBQLN2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000051108 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031770 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kokame K, Agarwala KL, Kato H, Miyata T (October 2000). "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress". The Journal of Biological Chemistry. 275 (42): 32846–53. doi:10.1074/jbc.M002063200. PMID 10922362.
  6. van Laar T, Schouten T, Hoogervorst E, van Eck M, van der Eb AJ, Terleth C (March 2000). "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway". FEBS Letters. 469 (1): 123–31. doi:10.1016/S0014-5793(00)01253-9. PMID 10708769. S2CID 6419566.
  7. "Entrez Gene: HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1".
  8. Kim TY, Kim E, Yoon SK, Yoon JB (May 2008). "Herp enhances ER-associated protein degradation by recruiting ubiquilins". Biochemical and Biophysical Research Communications. 369 (2): 741–6. doi:10.1016/j.bbrc.2008.02.086. PMID 18307982.

Further reading


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