HLA-DR14

HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.

major histocompatibility complex, class II, DR14
Haplotypes groups DRA*01:DRB1*1401 DRA*01:DRB1*1402 DRA*01:DRB1*1403 DRA*01:DRB1*1404 ....
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *1401 to *1408 *1410
Symbol(s) HLA-DRB1
EBI-HLA DRB1*1401
EBI-HLA DRB1*1402
EBI-HLA DRB1*1403
EBI-HLA DRB1*1404
EBI-HLA DRB1*1405
EBI-HLA DRB1*1406
Shared data
Locus chr.6 6p21.31

Alleles

DR14, DR6 and other serotype recognition of some DRB1*14 alleles[1]
DRB1*DR14 DR6DR13Sample
allele%%%size (N)
1401741431942
140261139204
14037212237
140479880[2]
1405861058
1406371522117
14079010
1408254

[3]

1410>754

Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462

Disease associations

DRB1*1402: juvenile rheumatoid arthritis,[4] increased longevity in Okinawans.

Extended linkage

DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.[5]

Genetic Linkage

DR14 Haplotypes
DRADRB1DRB3
DR14(6)-DR52 *0101*1401*0201
*0101*1402*0201
*0101*1403*0101
DQA1DQB1DRB1
DR14-DQ5(5.3, 1) *0104*0503*1401
HLA-AHLA-BDRB1
A11-B35-DR14(6) *1101*3501*1401
A2-B51(5)-DR14(6) *0201*5101*1401

HLA-DR13 is genetically linked to HLA-DR52[6] and HLA-DQ5 (HLA-DQ1) serotypes.

References

  1. derived from IMGT/HLA
  2. DR1404 - 3%
  3. DR4 - 25%
  4. Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
  5. Niks EH, Kuks JB, Roep BO, et al. (2006). "Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5". Neurology. 66 (11): 1772–4. doi:10.1212/01.wnl.0000218159.79769.5c. PMID 16769963.
  6. Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270–6. doi:10.1016/j.humimm.2003.12.005. PMID 15041167.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.