Hepatoprotection

Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. This is opposite to hepatotoxicity.

Hepatoprotective molecules used in emergency medicine
  • Acetylcysteine is considered the hepatoprotective drug of choice when treating an overdose of acetaminophen/paracetamol.[1]
  • Silymarin is given intravenously to treat poisoning from Amanita mushrooms according to the Santa Cruz protocol devised by Dr Todd Mitchell at UCSC.

Herbs with potentially hepatoprotective constituents


References
  1. https://poisoncontrol.utah.edu/newsletters/pdfs/toxicology-today-archive/Vol7_No1.pdf
  2. Chien, CF; Wu, YT; Tsai, TH (Jan 2011). "Biological analysis of herbal medicines used for the treatment of liver diseases". Biomedical Chromatography. 25 (1–2): 21–38. doi:10.1002/bmc.1568. PMID 21204110.
  3. Ghosh, N; Ghosh, R; Mandal, V; Mandal, SC (Sep 2011). "Recent advances in herbal medicine for treatment of liver diseases". Pharmaceutical Biology. 49 (9): 970–88. doi:10.3109/13880209.2011.558515. PMID 21595500.
  4. Steinkellner, H; Rabot, S; Freywald, C; Nobis, E; Scharf, G; Chabicovsky, M; Knasmüller, S; Kassie, F (Sep 1, 2001). "Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens". Mutation Research. 480–481: 285–97. doi:10.1016/S0027-5107(01)00188-9. PMID 11506821.
  5. Andrographis paniculata http://www.stuartxchange.com/Sinta.html
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