Human viruses in water

Viruses are a major cause of human waterborne and water-related diseases. Waterborne diseases are caused by water that is contaminated by human and animal urine and feces that contain pathogenic microorganisms. A subject can get infected through contact with or consumption of the contaminated water. Viruses affect all living organisms from single cellular plants, bacteria and animal to the highest forms of plants and animals including human beings. Within a specific kingdom ( Plantae, Animalia, Fungi etc) the localization of viruses colonizing the host can vary: Some human viruses, for example, HIV, colonizes only the immune system, while influenza viruses on the other hand can colonize either the upper respiratory tract or the lower respiratory tract depending on the type (human Influenza virus or avian influenza viruses respectively).[1] Different viruses can have different routes of transmission; for example, HIV is directly transferred by contaminated body fluids from an infected host into the tissue or bloodstream of a new host while influenza is airborne and transmitted through inhalation of contaminated air containing viral particles by a new host. Research has also suggested that solid surface plays a role in the transmission of water viruses. In a experiments that used E.coli phages, Qβ, fr, T4, and MS2 confirmed that viruses survive on a solid surface longer compared to when they are in water. Because of this adaptation to survive longer on solid surfaces, viruses now have a prolonged opportunities to infect humans.[2] Enteric viruses primarily infect the intestinal tract through ingestion of food and water contaminated with viruses of fecal origin. Some viruses can be transmitted through all three routes of transmission.

Water virology started about half a century ago when scientists attempted to detect the polio virus in water samples.[3] Since then, other pathogenic viruses that are responsible for gastroenteritis, hepatitis, and many other virus strains have replaced enteroviruses as the main aim for detection in the water environment.[3]

History

Major outbreaks

Water virology was born after a large hepatitis outbreak transmitted through water was confirmed in New Delhi between December 1955 and January 1956.[4]

Viruses can cause massive human mortality. The smallpox virus killed an estimated 10 to 15 million human beings per year until 1967.[3] Smallpox was finally eliminated in 1977 by extinction of the virus through vaccination, and the impact of viruses such as influenza, poliomyelitis and measles are mainly controlled by vaccination.[4]

Despite advances in vaccination and prevention of viral diseases, it is estimated that in the 1980s a child died approximately every six seconds from diarrhea confirmed by WHO. Many cases of hepatitis A and/or E, both of which are enteric viruses, are typically transmitted by food and water. Extreme examples include the outbreak of 300,000 cases of hepatitis A and 25,000 cases of gastroenteritis in 1988 in Shanghai caused by shellfish harvested from a sewage polluted estuary.[5] In 1991, an outbreak of 79,000 cases of hepatitis E in Kanpur was ascribed to drinking polluted water.[3]

A more recent outbreak of Hepatitis E in South Sudan killed 88 people. Medecins Sans Frontieres (MSF) said it had treated almost 4,000 patients since the outbreak was identified in South Sudan in July 2012. In this outbreak, Hepatitis E, which causes liver infections, and was thought to be spread by drinking water contaminated with feces.[6] Even more recently In 2014, another Hepatitis E outbreak occurred in south Sudan refugee camp situated in Ethiopia. The outbreak, which began in April of 2014 and ended in January of 2015, claimed a total of twenty-one lives.[7]

Sewage contaminated water contains many viruses, over one hundred species are reported and can lead to diseases that affect human beings. For example, hepatitis, gastroenteritis, meningitis, fever, rash, and conjunctivitis can all be spread through contaminated water. More viruses are being discovered in water because of new detection and characterization methods, although only some of these viruses are human pathogens.[4]

Rotavirus, an example of human water viruses
FamilyGenusSpeciesCommon NameDisease Caused
AdenovirusMastadenovirusHuman mastadenovirus A through GadenovirusAdenovirus infection, pharyngitis, conjunctivitis, fever
AstrovirusMamastrovirusHuman astrovirusastrovirusGastroenteritis, diarrhea
CalicivirusNorovirusNorwalk virusnorovirus, winter vomiting bugGastroenteritis, fever
CoronaviridaeCoronavirinaeSARS coronavirusSARS-CoVSARS, gastroenteritis, respiratory disease
CoronaviridaeTorovirusHuman torovirustorovirusGastroenteritis
HepeviridaeOrthohepevirusOrthohepevirus AHepatitis E virus, HEVHepatitis E
PicornavirusEnterovirusEnterovirus ACoxsackie A virusHand, foot, and mouth disease, paralysis, meningitis, fever, respiratory disease, myocarditis, heart anomalies
PicornavirusEnterovirusEnterovirus BechovirusMeningitis, fever, respiratory disease, rush, gastroenteritis
PicornavirusEnterovirusEnterovirus CpoliovirusPolio
PicornavirusHepatovirusHepatovirus Ahepatitis A virus, HAVHepatitis A
PolyomaviridaePolyomavirusJC virusJC virusProgressive multifocal leukoencephalopathy
ReovirusRotavirusRotavirus A, B, & CrotavirusGastroenteritis

Virus survival in water

Viruses need a suitable environment to survive in. There are many characteristics that control the survival of viruses in water such as temperature, light, pH, salinity, organic matter, suspended solids or sediments, and air–water interfaces.

Temperature

Temperature has the highest effect on virus's survival in water since lower temperatures are the key to longer virus survival. For instance, an article published in 2018 noted that it takes one year for certain viruses including poliovirus and echovirus to decrease by a 5log unit at a temperature of 4°C, while it takes only a week to obtain same result at a temperature of 37°C (human body temperature). The rate of protein, nucleic acid denaturation and chemical reactions that destroy the viral capsid are increased at higher temperatures, thus viruses will survive best at low temperatures. Hepatitis A, adenoviruses and parvoviruses have the highest survival rate in low temperatures amongst enteric viruses.[3][8]

Light

Ultraviolet light (UV) is the light in sunlight and can inactivate viruses by causing cross-linking of the nucleotides in the viral genome. Many viruses in water are exterminated in the presence of sunlight. The combination of higher temperatures and more UV in the summer time corresponds to shorter viral survival in summer compared to winter. Double stranded DNA viruses like adenoviruses are more resistant to UV light inactivation than enteroviruses because they can use their host cell to repair the damage caused by the UV light.[3]

Visible light can also affect virus survival by a process called photodynamic inactivation but the length and intensity of the light exposure can change the inactivation rate.[3]

pH

The pH of most natural water is between 5–9. Enteric viruses are stable in these conditions. On the other hand, many enteric viruses are more stable at pH 3-5 than at pH 9 and 12. Enteroviruses can survive at pH 11–11.5 and 1–2, but for only short periods. Adenoviruses and rotaviruses are delicate to a pH of 10 or greater and leads to inactivation.[3]

Salts and Metals:

In a general perspective, viruses don't survive in areas with high concentration of salt. Thus, viruses can live longer in a freshwater habitat than water bodies with high salt concentration. It is also known that certain heavy metals are toxic to viruses. [9]


Interface.                                                                         

Some types of coliphages (a type of bacteriophage) are inactive in an of air-water-solid interface. This is due to the unfolding of the viruses' protein capsid (which is a crucial component for infecting the host). Aggravation of this effect is seen when the ionic strength of the solution increases[4]

Aggregation

Aggregation is the one of the most known methods for the survival of viruses. In a liquid environment, viruses tend to form a clump (aggregation). This aggregation result in a reduced rate of virus inactivation promptly showing that viral particles that do not aggregate are more easily destroyed. It has also been proven that aggregation may form spontaneously or may result by nucleation on particles of water.[8]

Virus removal from water

Water that is intended for drinking should go through some treatment to reduce pathogenic viral and bacterial concentrations. As the density of the human population has increased the incidence of sewage contamination of water has increased as well, thus the risk to humans from pathogenic viruses will increase if precautions are not taken.[3]

Scientific studies suggest that the most common viruses found are caliciviruses, astroviruses and enteric viruses. Laboratories are still looking for improved methods to detect these pathogenic viruses. Reducing the amount of viruses in drinking water is accomplished by various treatments that are typically part of drinking water treatment systems in developed countries.[3][10]

Water purification of surface water (water from lakes, rivers, or reservoirs) typically utilizes four treatment stages: coagulation and flocculation, sedimentation, filtration, and disinfection. The first three stages remove mainly dirt and larger particles, although filtration does reduce the number of viruses and bacteria in the water the number of pathogens present after filtration is still considered too high for drinking water. Purification of water from underground aquifers, called ground water, may skip some of these steps as ground water tends to have fewer contaminants than surface water. The last step, disinfection, is primarily responsible for the reduction of pathogenic viruses to safe levels in all drinking water sources. The most common disinfectants used are chlorine and chloramine. Ozone and UV light can also be used to treat large volumes of water to remove pathogens.[10]

In an article published in 2010, it was determined that nanoparticles of silver could significantly inactivate the activity of some water viruses. When 5.4 ml of the nanoparticles of silver was added to a water virus, its activity decreased by 4log.[11]

Prevention of water viruses

The quality of drinking water is ensured through a framework of water safety plans that ensures the safe disposal of human waste so that drinking water supplies are not contaminated. Improving the water supply, sanitation, hygiene and management of our water resources could prevent ten percent of total global disease.[12]

Half of the hospital beds occupied in the world are related to the lack of safe drinking water. Unsafe water leads to the 88% of the global cases of diarrhea and 90% of the deaths of diarreaheal diseases in children under five years old. Most of these deaths occur in developing countries due to poverty and the high cost of safe water.[12] An article published in 2003 by CDC concluded that the death of children (less than five years of age) caused by rotavirus on a global scale ranges between 352,000 to 592,000.[13]

Approximately 1.1 billion people do not have access to improved water and 2.4 billion people do not have access to sanitation facilities. This situation leads to 2 million preventable deaths each year.[14]

See also

References
  1. "Influenza: Insights Into Cell Specificity Of Human Vs. Avian Viruses". ScienceDaily. 10 October 2007. Retrieved 10 May 2020.
  2. Sakoda A, Sakai Y, Hayakawa K, Suzuki M (1 January 1997). "Adsorption of viruses in water environment onto solid surfaces". Water Science and Technology. Adsorption in the Water Environment and Treatment Processes. 35 (7): 107–114. doi:10.1016/S0273-1223(97)00120-0. ISSN 0273-1223. Retrieved 10 May 2020.
  3. Bosch, Albert, ed. (2007). Human viruses in water. Amsterdam: Elsevier. ISBN 9780080553276.
  4. Bosch A (September 1998). "Human enteric viruses in the water environment: a minireview". Int Microbiol. 1 (3): 191–196. doi:10.3201/eid0905.020562. PMC 2972763. PMID 12737740. Retrieved 7 September 2020.
  5. Potasman I, Paz A, Odeh M (15 October 2002). "Infectious Outbreaks Associated with Bivalve Shellfish Consumption: A Worldwide Perspective". Clin Infect Dis. 35 (8): 921–928. doi:10.1086/342330. PMID 12355378.
  6. Holland H (2 February 2013). "Hepatitis outbreak kills 88 in South Sudan: aid agency". Reuters. Retrieved 6 May 2013.
  7. "Notes from the Field: Hepatitis E Outbreak Among Refugees from South Sudan — Gambella, Ethiopia, April 2014–January 2015". CDC. Retrieved 10 May 2020.
  8. Pinon A, Vialette M (2018). "Survival of Viruses in Water". Intervirology. 61 (5): 214–222. doi:10.1159/000484899. PMID 29316545. Retrieved 10 May 2020.
  9. Bosch, Albert (2007). Human Viruses In Water: Perspective in Medical Virology. ProQuest Ebook Central: Elsevier Science & Technology. p. 94. ISBN 9780444521576.
  10. "Water Treatment". Center for Disease Control. Retrieved 24 May 2013.
  11. Bart De, De Gusseme (2010). "Inactivation of Viruses in Water by Biogenic Silver: Innovative and Environmentally Friendly Disinfection Technique". ebscohost. Retrieved 29 April 2020.
  12. "Water facts: Disease". water org. Archived from the original on 30 April 2013. Retrieved 6 May 2013.
  13. Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI (May 2003). "Global illness and deaths caused by rotavirus disease in children". Emerg Infect Dis. 9 (5): 565–572. doi:10.3201/eid0905.020562. PMC 2972763. PMID 12737740.
  14. "Meeting the MDG Drinking Water and Sanitation target: The urban and rural challenge of the decade" (PDF). World Health Organization. WHO. 2006. Retrieved 6 May 2013.
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