KIAA1967

KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.[5][6][7]

CCAR2
Identifiers
AliasesCCAR2, DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC, cell cycle and apoptosis regulator 2
External IDsOMIM: 607359 MGI: 2444228 HomoloGene: 10910 GeneCards: CCAR2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p21.3Start22,604,632 bp[1]
End22,621,514 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57805

219158

Ensembl

ENSG00000158941

ENSMUSG00000033712

UniProt

Q8N163

Q8VDP4

RefSeq (mRNA)

NM_021174
NM_199205
NM_001363068
NM_001363069

NM_146055

RefSeq (protein)

NP_066997
NP_001349997
NP_001349998

NP_666167

Location (UCSC)Chr 8: 22.6 – 22.62 MbChr 14: 70.14 – 70.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylates histones and p53.[8][9] DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000158941 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033712 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: KIAA1967 KIAA1967".
  6. Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
  7. Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH (October 2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647–52. doi:10.1073/pnas.212516099. PMC 129730. PMID 12370419.
  8. Kim JE, Chen J, Lou Z (January 2008). "DBC1 is a negative regulator of SIRT1". Nature. 451 (7178): 583–6. doi:10.1038/nature06500. PMID 18235501. S2CID 4420753.
  9. Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W (January 2008). "Negative regulation of the deacetylase SIRT1 by DBC1". Nature. 451 (7178): 587–90. doi:10.1038/nature06515. PMC 2866287. PMID 18235502.
  10. Anantharaman V, Aravind L (May 2008). "Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites". Cell Cycle. 7 (10): 1467–72. doi:10.4161/cc.7.10.5883. PMC 2423810. PMID 18418069.

Further reading


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