KLK4

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.[5][6][7]

KLK4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLK4, AI2A1, ARM1, EMSP, EMSP1, KLK-L1, PRSS17, PSTS, kallikrein, kallikrein related peptidase 4
External IDsOMIM: 603767 MGI: 1861379 HomoloGene: 55856 GeneCards: KLK4
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.41Start50,906,352 bp[1]
End50,910,738 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9622

56640

Ensembl

ENSG00000167749

ENSMUSG00000006948

UniProt

Q9Y5K2

Q9Z0M1

RefSeq (mRNA)

NM_001302961
NM_004917

NM_019928

RefSeq (protein)

NP_001289890
NP_004908

NP_064312

Location (UCSC)Chr 19: 50.91 – 50.91 MbChr 7: 43.88 – 43.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikreins are a subgroup of serine proteases having diverse physiological functions.[8] Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In particular, they may serve as biomarkers for both prostate cancer and breast cancer.

This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins.[9] Alternate splice variants for this gene have been described, but their biological validity has not been determined.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000167749 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000006948 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (February 1998). "Purification, characterization, and cloning of enamel matrix serine proteinase 1". Journal of Dental Research. 77 (2): 377–86. doi:10.1177/00220345980770020601. PMID 9465170. S2CID 21816663. Archived from the original on 2008-08-21. Retrieved 2008-10-20.
  6. Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K (March 1999). "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression". Proceedings of the National Academy of Sciences of the United States of America. 96 (6): 3114–9. doi:10.1073/pnas.96.6.3114. PMC 15904. PMID 10077646.
  7. Stephenson SA, Verity K, Ashworth LK, Clements JA (August 1999). "Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4". The Journal of Biological Chemistry. 274 (33): 23210–4. doi:10.1074/jbc.274.33.23210. PMID 10438493.
  8. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
  9. Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (June 2000). "Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors". Gene. 251 (1): 1–8. doi:10.1016/S0378-1119(00)00203-1. PMID 10863090. Archived from the original on 2008-08-21. Retrieved 2008-10-20.
  10. "Entrez Gene: KLK4 kallikrein-related peptidase 4".

Further reading

  • The MEROPS online database for peptidases and their inhibitors: S01.251
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