KPNA4

karyopherin subunit alpha-4, also known as importin alpha-3, is a protein that in humans is encoded by the KPNA4 gene.[5][6]

KPNA4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKPNA4, IPOA3, QIP1, SRP3, karyopherin subunit alpha 4
External IDsOMIM: 602970 MGI: 1100848 HomoloGene: 20521 GeneCards: KPNA4
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q25.33Start160,495,007 bp[1]
End160,565,571 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3840

16649

Ensembl

ENSG00000186432

ENSMUSG00000027782

UniProt

O00629

O35343

RefSeq (mRNA)

NM_002268

NM_008467

RefSeq (protein)

NP_002259

NP_032493

Location (UCSC)Chr 3: 160.5 – 160.57 MbChr 3: 69.07 – 69.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.[7]

Interactions

KPNA4 has been shown to interact with RECQL[5] and STAT3.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000186432 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027782 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seki T, Tada S, Katada T, Enomoto T (May 1997). "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL". Biochemical and Biophysical Research Communications. 234 (1): 48–53. doi:10.1006/bbrc.1997.6535. PMID 9168958.
  6. Köhler M, Ansieau S, Prehn S, Leutz A, Haller H, Hartmann E (Nov 1997). "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family". FEBS Letters. 417 (1): 104–8. doi:10.1016/S0014-5793(97)01265-9. PMID 9395085. S2CID 84237136.
  7. "Entrez Gene: KPNA4 karyopherin alpha 4 (importin alpha 3)".
  8. Liu L, McBride KM, Reich NC (Jun 2005). "STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3". Proc Natl Acad Sci U S A. 102 (23): 8150–5. doi:10.1073/pnas.0501643102. PMC 1149424. PMID 15919823.

Further reading


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