Kynurenate-7,8-dihydrodiol dehydrogenase
In enzymology, a kynurenate-7,8-dihydrodiol dehydrogenase (EC 1.3.1.18) is an enzyme that catalyzes the chemical reaction
- 7,8-dihydro-7,8-dihydroxykynurenate + NAD+ 7,8-dihydroxykynurenate + NADH + H+
| kynurenate-7,8-dihydrodiol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.18 | ||||||||
| CAS number | 37255-30-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 7,8-dihydro-7,8-dihydroxykynurenate and NAD+, whereas its 3 products are 7,8-dihydroxykynurenate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase. Other names in common use include 7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase, and 7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase. This enzyme participates in tryptophan metabolism.
References
- Taniuchi H, Hayaishi O (January 1963). "Studies on the metabolism of kynurenic acid. III. Enzymatic formation of 7,8-dihydroxykynurenic acid from kynurenic acid". The Journal of Biological Chemistry. 238: 283–93. PMID 13984873.
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