L-rhamnose isomerase

In enzymology, a L-rhamnose isomerase (EC 5.3.1.14) is an enzyme that catalyzes the chemical reaction

L-rhamnose L-rhamnulose
L-rhamnose isomerase
Identifiers
EC number5.3.1.14
CAS number9023-84-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, L-rhamnose, and one product, L-rhamnulose.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is L-rhamnose aldose-ketose-isomerase. Other names in common use include rhamnose isomerase, and L-rhamnose ketol-isomerase. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1D8W, 1DE5, 1DE6, 2HCV, 2I56, and 2I57.

References

    • DOMAGK GF, ZECH R (1963). "On the Decomposition of Desoxy Sugars by Bacterial Enzymes. I. L-Rhamnose Isomerase from Lactobacillus Plantarum". Biochem. Z. 339: 145–53. PMID 14095156.


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