Prostaglandin E synthase
Prostaglandin E synthase (or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.[2][3]
| prostaglandin-E synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 5.3.99.3 | ||||||||
| CAS number | 52227-79-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The synthase generating PGE2 is a membrane-associated protein.
Biosynthesis of eicosanoids.
Isozymes
Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene:
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References
- Jegerschold, C.; Pawelzik, S. -C.; Purhonen, P.; Bhakat, P.; Gheorghe, K. R.; Gyobu, N.; Mitsuoka, K.; Morgenstern, R.; Jakobsson, P. -J.; Hebert, H. (2008). "Structural basis for induced formation of the inflammatory mediator prostaglandin E2". Proceedings of the National Academy of Sciences. 105 (32): 11110–11115. doi:10.1073/pnas.0802894105. PMC 2516235. PMID 18682561.
- Murakami M, Nakatani Y, Tanioka T, Kudo I (August 2002). "Prostaglandin E synthase". Prostaglandins Other Lipid Mediat. 68–69: 383–99. doi:10.1016/S0090-6980(02)00043-6. PMID 12432931.
- Park JY, Pillinger MH, Abramson SB (June 2006). "Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases". Clin. Immunol. 119 (3): 229–40. doi:10.1016/j.clim.2006.01.016. PMID 16540375.
External links
- prostaglandin-E+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 5.3.99.3
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