LDB1

LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.[5][6][7]

LDB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLDB1, CLIM2, NLI, CLIM-2, LDB-1, LIM domain binding 1
External IDsOMIM: 603451 MGI: 894762 HomoloGene: 2891 GeneCards: LDB1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q24.32Start102,106,489 bp[1]
End102,120,368 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8861

16825

Ensembl

ENSG00000198728

ENSMUSG00000025223

UniProt

Q86U70

P70662

RefSeq (mRNA)

NM_001113407
NM_003893
NM_001321612

NM_001113408
NM_010697
NM_001360336

RefSeq (protein)

NP_001106878
NP_001308541
NP_003884

NP_001106879
NP_034827
NP_001347265

Location (UCSC)Chr 10: 102.11 – 102.12 MbChr 19: 46.03 – 46.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

LDB1 has been shown to interact with LMO4,[8][9] TCF3,[10] TAL1[10] and CBFA2T3.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000198728 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025223 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamashita T, Agulnick AD, Copeland NG, Gilbert DJ, Jenkins NA, Westphal H (Apr 1998). "Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1". Genomics. 48 (1): 87–92. doi:10.1006/geno.1997.5163. PMID 9503020.
  6. Semina EV, Altherr MR, Murray JC (Dec 1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm Genome. 9 (11): 921–4. doi:10.1007/s003359900899. PMID 9799849. S2CID 28813194.
  7. "Entrez Gene: LDB1 LIM domain binding 1".
  8. Sutherland, Kate D; Visvader Jane E; Choong David Y H; Sum Eleanor Y M; Lindeman Geoffrey J; Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi:10.1002/ijc.11343. ISSN 0020-7136. PMID 12925972. S2CID 20908722.
  9. Deane, Janet E; Mackay Joel P; Kwan Ann H Y; Sum Eleanor Y M; Visvader Jane E; Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN 0261-4189. PMC 156068. PMID 12727888.
  10. Goardon, Nicolas; Lambert Julie A; Rodriguez Patrick; Nissaire Philippe; Herblot Sabine; Thibault Pierre; Dumenil Dominique; Strouboulis John; Romeo Paul-Henri; Hoang Trang (Jan 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. ISSN 0261-4189. PMC 1383517. PMID 16407974.

Further reading

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