MAGEA10

MAGEA10
Identifiers
Aliases	MAGEA10, CT1.10, MAGE10, MAGE family member A10
External IDs	OMIM: 300343 MGI: 3588211 HomoloGene: 121621 GeneCards: MAGEA10
Gene location (Human)
Chr.	X chromosome (human)[1]
End	152,138,578 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	72,386,858 bp[2]
Orthologs
	4109
	236852
	ENSG00000124260
	ENSMUSG00000043453
	P43363
	A2AMW4
	NM_021048; NM_001011543; NM_001251828
	NM_001085506
	NP_001011543; NP_001238757; NP_066386
	NP_001078975
	Wikidata
View/Edit Human	View/Edit Mouse

MAGE family member A10 is a protein that in humans is encoded by the MAGEA10 gene. [5]

Function

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls.

The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.

References

GRCh38: Ensembl release 89: ENSG00000124260 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000043453 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: MAGE family member A10". Retrieved 2017-06-15.

Lin J, Lin L, Thomas DG, Greenson JK, Giordano TJ, Robinson GS, Barve RA, Weishaar FA, Taylor JM, Orringer MB, Beer DG (2004). "Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants". Clin. Cancer Res. 10 (17): 5708–16. doi:10.1158/1078-0432.CCR-04-0468. PMID 15355897.
Schultz-Thater E, Piscuoglio S, Iezzi G, Le Magnen C, Zajac P, Carafa V, Terracciano L, Tornillo L, Spagnoli GC (2011). "MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies". Int. J. Cancer. 129 (5): 1137–48. doi:10.1002/ijc.25777. PMID 21710496.
Badovinac Črnjević T, Tanja BČ, Spagnoli G, Giulio S, Juretić A, Antonio J, Jakić-Razumović J, Jasminka JR, Podolski P, Paula P, Šarić N, Nera Š (2012). "High expression of MAGE-A10 cancer-testis antigen in triple-negative breast cancer". Med. Oncol. 29 (3): 1586–91. doi:10.1007/s12032-011-0120-9. PMID 22116775.
Wang L, Xu Y, Luo C, Sun J, Zhang J, Lee MW, Bai A, Chen G, Frenz CM, Li Z, Huang W (2015). "MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles". Cell. Immunol. 297 (1): 10–8. doi:10.1016/j.cellimm.2015.05.004. PMID 26058806.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124260 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043453 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MAGE family member A10". Retrieved 2017-06-15.

MAGEA10

Function

References

Further reading