MCRS1

Microspherule protein 1 is a protein that in humans is encoded by the MCRS1 gene.[5][6][7]

MCRS1
Identifiers
AliasesMCRS1, ICP22BP, INO80Q, MCRS2, MSP58, P78, microspherule protein 1
External IDsOMIM: 609504 MGI: 1858420 HomoloGene: 4622 GeneCards: MCRS1
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.12Start49,556,544 bp[1]
End49,568,145 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10445

51812

Ensembl

ENSG00000187778

ENSMUSG00000037570

UniProt

Q96EZ8

Q99L90

RefSeq (mRNA)

NM_001012300
NM_001278341
NM_006337

NM_001164156
NM_016766

RefSeq (protein)

NP_001012300
NP_001265270
NP_006328

NP_001157628
NP_058046

Location (UCSC)Chr 12: 49.56 – 49.57 MbChr 15: 99.24 – 99.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

MCRS1 has been shown to interact with PHC2,[8] Death associated protein 6,[9] NOL1,[6] PINX1[10] and Telomerase reverse transcriptase.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000187778 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037570 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bruni R, Roizman B (Nov 1998). "Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells". Journal of Virology. 72 (11): 8525–31. doi:10.1128/JVI.72.11.8525-8531.1998. PMC 110262. PMID 9765390.
  6. Ren Y, Busch RK, Perlaky L, Busch H (May 1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120". European Journal of Biochemistry / FEBS. 253 (3): 734–42. doi:10.1046/j.1432-1327.1998.2530734.x. PMID 9654073.
  7. "Entrez Gene: MCRS1 microspherule protein 1".
  8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  9. Lin DY, Shih HM (Jul 2002). "Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration". The Journal of Biological Chemistry. 277 (28): 25446–56. doi:10.1074/jbc.M200633200. PMID 11948183.
  10. Song H, Li Y, Chen G, Xing Z, Zhao J, Yokoyama KK, Li T, Zhao M (Apr 2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length". Biochemical and Biophysical Research Communications. 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. PMID 15044100.

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.