NOL1

Putative ribosomal RNA methyltransferase NOP2 is an enzyme that in humans is encoded by the NOP2 gene.[5][6]

NOP2
Identifiers
AliasesNOP2, NOL1, NOP120, NSUN1, p120, NOP2 nucleolar protein
External IDsOMIM: 164031 MGI: 107891 HomoloGene: 135865 GeneCards: NOP2
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.31Start6,556,863 bp[1]
End6,568,691 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4839

110109

Ensembl

ENSG00000111641

ENSMUSG00000038279

UniProt

P46087

Q922K7

RefSeq (mRNA)

NM_001033714
NM_001258308
NM_001258309
NM_001258310
NM_006170

NM_138747

RefSeq (protein)

NP_001028886
NP_001245237
NP_001245238
NP_001245239
NP_006161

n/a

Location (UCSC)Chr 12: 6.56 – 6.57 MbChr 6: 125.13 – 125.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a nucleolar antigen expressed in proliferating cells. It is not detectable in non-proliferating normal tissue but is detectable in many human tumors.[7]

Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the transformed cells to revert to their original non-malignant phenotype.[8] The p120 protein displays a dramatic increase in expression at the G1/S transition suggesting that p120 regulates the cell cycle and nucleolar activity that is required for cell proliferation.[9]

Interactions

NOL1 has been shown to interact with MCRS1.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000111641 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038279 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Baens M, Chaffanet M, Aerssens J, Cassiman JJ, Marynen P (October 1994). "Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids". Genomics. 21 (1): 296–7. doi:10.1006/geno.1994.1267. PMID 8088812.
  6. "Entrez Gene: NOL1 nucleolar protein 1, 120kDa".
  7. Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H (1 March 1988). "Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase". Cancer Res. 48 (5): 1244–51. PMID 3422591.
  8. Perlaky L, Valdez BC, Busch RK, Larson RG, Jhiang SM, Zhang WW, Brattain M, Busch H (January 1992). "Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct". Cancer Res. 52 (2): 428–36. PMID 1728415.
  9. Fonagy A, Swiderski C, Wilson A, Bolton W, Kenyon N, Freeman JW (January 1993). "Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts". J. Cell. Physiol. 154 (1): 16–27. doi:10.1002/jcp.1041540104. PMID 8419402. S2CID 45238441.
  10. Ren Y, Busch RK, Perlaky L, Busch H (May 1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120". Eur. J. Biochem. 253 (3): 734–42. doi:10.1046/j.1432-1327.1998.2530734.x. PMID 9654073.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.