MFN1

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.[5][6][7]

MFN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMFN1, hfzo1, hfzo2, mitofusin 1
External IDsOMIM: 608506 MGI: 1914664 HomoloGene: 11481 GeneCards: MFN1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q26.33Start179,347,709 bp[1]
End179,394,936 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

55669

67414

Ensembl

ENSG00000171109

ENSMUSG00000027668

UniProt

Q8IWA4

Q811U4

RefSeq (mRNA)

NM_017927
NM_033540

NM_024200

RefSeq (protein)

NP_284941

NP_077162

Location (UCSC)Chr 3: 179.35 – 179.39 MbChr 3: 32.53 – 32.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000171109 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027668 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat Genet. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434. S2CID 20528590.
  6. Santel A, Fuller MT (Feb 2001). "Control of mitochondrial morphology by a human mitofusin". J Cell Sci. 114 (Pt 5): 867–74. PMID 11181170.
  7. "Entrez Gene: MFN1 mitofusin 1".

Further reading


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