MGST2

MGST2
Identifiers
Aliases	MGST2, GST2, MGST-II, microsomal glutathione S-transferase 2
External IDs	OMIM: 601733 MGI: 2448481 HomoloGene: 1811 GeneCards: MGST2
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	139,740,745 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	51,682,677 bp[2]
Gene ontology
Molecular function	• GO:0010577 enzyme activator activity; • leukotriene-C4 synthase activity; • transferase activity; • glutathione transferase activity; • GO:0001948 protein binding; • glutathione peroxidase activity;
Cellular component	• integral component of membrane; • intracellular membrane-bounded organelle; • organelle membrane; • cell membrane; • cytoplasm; • endoplasmic reticulum membrane; • endoplasmic reticulum; • nuclear envelope; • membrane;
Biological process	• glutathione derivative biosynthetic process; • leukotriene metabolic process; • leukotriene biosynthetic process; • glutathione biosynthetic process; • response to lipopolysaccharide; • GO:0048554 positive regulation of catalytic activity; • response to organonitrogen compound; • xenobiotic metabolic process; • cellular oxidant detoxification; • lipid metabolism; • membrane lipid catabolic process; • positive regulation of inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	4258
	211666
	ENSG00000085871
	ENSMUSG00000074604
	Q99735
	A2RST1
	NM_001204366; NM_001204367; NM_001204368; NM_002413
	NM_174995; NM_001310482
	NP_001191295; NP_001191296; NP_001191297; NP_002404
	NP_001297411; NP_778160
	Wikidata
View/Edit Human	View/Edit Mouse

Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene.[5][6]

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.[6]

References

GRCh38: Ensembl release 89: ENSG00000085871 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000074604 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jakobsson PJ, Mancini JA, Ford-Hutchinson AW (Oct 1996). "Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase". J Biol Chem. 271 (36): 22203–10. doi:10.1074/jbc.271.36.22203. PMID 8703034.
"Entrez Gene: MGST2 microsomal glutathione S-transferase 2".

Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4. doi:10.1164/ajrccm.161.supplement_1.ltta-5. PMID 10673221.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities". J. Biol. Chem. 272 (36): 22934–9. doi:10.1074/jbc.272.36.22934. PMID 9278457.
Jakobsson PJ, Scoggan KA, Yergey J, et al. (1998). "Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer". Journal of Lipid Mediators and Cell Signalling. 17 (1): 15–9. doi:10.1016/S0929-7855(97)00013-8. PMID 9302651.
Sjöström M, Jakobsson PJ, Heimburger M, et al. (2001). "Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor". Eur. J. Biochem. 268 (9): 2578–86. doi:10.1046/j.1432-1327.2001.02142.x. PMID 11322876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yang S, Yan KL, Zhang XJ, et al. (2006). "Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population". Arch. Dermatol. Res. 298 (3): 107–12. doi:10.1007/s00403-006-0670-4. PMID 16773312. S2CID 20923145.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000085871 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074604 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8703034-5] Jakobsson PJ, Mancini JA, Ford-Hutchinson AW (Oct 1996). "Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase". J Biol Chem. 271 (36): 22203–10. doi:10.1074/jbc.271.36.22203. PMID 8703034.

[entrez-6] "Entrez Gene: MGST2 microsomal glutathione S-transferase 2".

MGST2

References

Further reading