MLLT3

Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.[5][6][7]

MLLT3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMLLT3, AF9, YEATS3, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3, super elongation complex subunit, MLLT3 super elongation complex subunit
External IDsOMIM: 159558 MGI: 1917372 HomoloGene: 37933 GeneCards: MLLT3
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9p21.3Start20,341,669 bp[1]
End20,622,518 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4300

70122

Ensembl

ENSG00000171843

ENSMUSG00000028496

UniProt

P42568

A2AM29

RefSeq (mRNA)

NM_004529
NM_001286691

NM_001286158
NM_027326
NM_029931

RefSeq (protein)

NP_001273620
NP_004520

NP_001273087
NP_081602
NP_084207

Location (UCSC)Chr 9: 20.34 – 20.62 MbChr 4: 87.77 – 88.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

MLLT3 has been shown to interact with BCOR.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000171843 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028496 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al. (Jul 1993). "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs". Proc Natl Acad Sci U S A. 90 (10): 4631–5. Bibcode:1993PNAS...90.4631N. doi:10.1073/pnas.90.10.4631. PMC 46566. PMID 8506309.
  6. Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (Nov 1993). "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13". Oncogene. 8 (11): 3085–92. PMID 8414510.
  7. "Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3".
  8. Srinivasan, R Sathish; de Erkenez Andrea C; Hemenway Charles S (May 2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. ISSN 0950-9232. PMID 12776190.

Further reading


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