MX2

Interferon-induced GTP-binding protein MX2/MXB is a protein that in humans is encoded by the MX2 gene.[3][4][5]

MX2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4WHJ, 4X0R
Identifiers
Aliases	MX2, MXB, MX dynamin like GTPase 2
External IDs	OMIM: 147890 HomoloGene: 74299 GeneCards: MX2
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 41,361,999 bp[1] End 41,409,393 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • GO:0001948 protein binding • microtubule binding • GTPase activity Cellular component • cytosol • cytoplasm • nuclear pore • cell nucleus • mitochondrial membranes • membrane Biological process • defense response • regulation of nucleocytoplasmic transport • mRNA transport • immune system process • response to virus • regulation of cell cycle • defense response to virus • type I interferon signaling pathway • response to interferon-alpha • protein transport • innate immune system • mitochondrial fission • dynamin family protein polymerization involved in mitochondrial fission • Lipid bilayer fusion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4600	n/a
Ensembl	ENSG00000183486	n/a
UniProt	P20592	n/a
RefSeq (mRNA)	NM_002463	n/a
RefSeq (protein)	NP_002454	n/a
Location (UCSC)	Chr 21: 41.36 – 41.41 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

For the aircraft and other subjects see MX2 (disambiguation)

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.[5]

MX2/MXB has antiviral activity against HIV-1.[6][7][8][9] MXB is also a restriction factor for herpesviruses, which acts at a very early stage of the replication cycle and MX2/MXB restriction of herpesvirus requires GTPase activity.[10][11][12][13]