MYL1

Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene.[5][6][7]

MYL1
Identifiers
AliasesMYL1, MLC1F, MLC3F, myosin light chain 1, MYOFTA
External IDsOMIM: 160780 MGI: 97269 HomoloGene: 23194 GeneCards: MYL1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q34Start210,290,150 bp[1]
End210,315,174 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4632

17901

Ensembl

ENSG00000168530

ENSMUSG00000061816

UniProt

P05976

P05977

RefSeq (mRNA)

NM_079422
NM_079420

NM_001113387
NM_021285

RefSeq (protein)

NP_524144
NP_524146

NP_001106858
NP_067260

Location (UCSC)Chr 2: 210.29 – 210.32 MbChr 1: 66.92 – 66.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000168530 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000061816 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.
  6. Cohen-Haguenauer O, Barton PJ, Nguyen VC, Serero S, Gross MS, Jegou-Foubert C, de Tand MF, Robert B, Buckingham M, Frezal J (Mar 1988). "Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter". Hum Genet. 78 (1): 65–70. doi:10.1007/BF00291237. PMID 3422212. S2CID 24782863.
  7. "Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast".

Further reading


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