MYLIP

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.[5]

MYLIP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYLIP, IDOL, MIR, myosin regulatory light chain interacting protein
External IDsOMIM: 610082 MGI: 2388271 HomoloGene: 8309 GeneCards: MYLIP
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.3Start16,129,086 bp[1]
End16,148,248 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

29116

218203

Ensembl

ENSG00000007944

ENSMUSG00000038175

UniProt

Q8WY64

Q8BM54

RefSeq (mRNA)

NM_013262

NM_153789

RefSeq (protein)

NP_037394

NP_722484

Location (UCSC)Chr 6: 16.13 – 16.15 MbChr 13: 45.39 – 45.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation.[6][7] The expression of IDOL is induced by the sterol-activated liver X receptor.

Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.[8] Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.

Function

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000007944 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038175 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: MYLIP myosin regulatory light chain interacting protein".
  6. Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science. 325 (5936): 100–4. Bibcode:2009Sci...325..100Z. doi:10.1126/science.1168974. PMC 2777523. PMID 19520913.
  7. Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMID 19688294. S2CID 34153384.
  8. Sawamura, T. (2009). "New Idol for cholesterol reduction?". Clin. Chem. 55 (12): 2082–2084. doi:10.1373/clinchem.2009.134023. PMID 19833835.

Further reading


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