Mammary myofibroblastoma

Mammary myofibroblastoma (MMFB) is a rare, benign tumor of the breast.

Mammary myofibroblastoma
Other namesWargotz tumor
Micrograph of mammary myofibroblastoma. H&E stain.
SpecialtyPathology

Symptoms

These tumors are painless masses that manifest as breast lumps and may be found on a mammogram.

Diagnosis

The diagnosis is based on examination under a microscope, by a pathologist. Radiologic findings may be suggestive, as these tumors are well-circumscribed and devoid of calcifications.

Pathology

Myofibroblastoma of the breast, first described by Wargotz et al. {Am J Surg Pathol. 1987 Jul;11(7):493-502} consist of bland spindle cells arranged in fascicles with interspersed thick bundles of collagen.[1] They typically stain with CD34 and desmin.[1]

In extra-mammary sites the tumour is known as a mammary-type myofibroblastoma, and may immunohistochemically and histomorphologically overlap with spindle cell lipoma.[2]

  • Intermed. mag.
  • High mag.

Treatment

Mammary myofibroblastomas are cured if completely excised.

See also

References
  1. Mele, M.; Jensen, V.; Wronecki, A.; Lelkaitis, G. (2011). "Myofibroblastoma of the breast: Case report and literature review". Int J Surg Case Rep. 2 (6): 93–6. doi:10.1016/j.ijscr.2011.02.006. PMC 3199680. PMID 22096693.
  2. McMenamin, ME.; Fletcher, CD. (Aug 2001). "Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma". Am J Surg Pathol. 25 (8): 1022–9. doi:10.1097/00000478-200108000-00006. PMID 11474286.
Classification
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