Mana Khemia: Alchemists of Al-Revis

Vayne Aurelius (ヴェイン・アウレオルス, Vain Aureorusu)

Voiced by: Akira Ishida

Vayne is the protagonist and main character, who lives alone deep in the forest with Sulpher, a black cat. Suddenly one day, he is invited to come to Al-Revis Academy, supposedly because his is the son of a famous alchemist. He is shy and has a weak personality, and his friends talk him into trouble. He performs several miraculous acts as the game progresses, and it is eventually revealed that he is an artificial Mana, created by his famous alchemist father, who is able to grant wishes. Depending on his relationship with others, he will either continue to live on knowing that he is the Mana of wishes, or choose to disappear from the world. In all the good endings, Vayne eventually saves his friends and the school by wishing his power away.

Jessica Philomele (フィロメール・アルトゥング, Firomēru Arutungu)

Voiced by: Sakura Nogawa

Vayne's classmate, Jessica, fears no one. She has a very friendly and outgoing personality, but is slightly klutzy. She loves alchemy, and tests her strangely unique syntheses whenever she has the time, always causing something to explode. Since she was little, she had a strange illness that no doctors could fix until the legendary alchemist, Theofratus, managed to cure her. He made a mistake in the process and, as a result, her life expectancy has been greatly reduced. In her ending, Vayne becomes her doctor, working to cure her along with the other members of her workshop. Her bag appears to be some kind of magical device, akin to a bag of holding, however she is also able to pull out items that were never placed inside.

Flay Gunnar (グンナル・ダム, Gunnaru Damu)

Voiced by: Kenyuu Horiuchi

Vayne's schoolmate Flay is one year his senior. He is known throughout the school as a troublemaker. On Orientation Day, he forced Vayne to join his workshop, along with Jess and Nikki. As long as he is having fun, he does not care about anyone else's troubles. He also loves an adventurous, non-boring world. He always wants to be a 'King of Justice' aka a Superhero, and drags Vayne with him as his partner hero. In his ending, Flay has become a villain (though most likely a playful one) named the "Flayvor of Evil" in the U.S. version, and Vayne is the hero who continually battles with him.

Nicole Mimi Tithel (ティティルミミニケメレ, Titiru Mimi Nike Mere)

Voiced by: Miyuki Sawashiro

An energetic beastman girl, Nikki talks and acts before she thinks. She hates sitting still inside a room, so she does not concentrate on her syntheses. She is too lazy to be in the academy, because she hates doing assignments. She grew up in a small village, which may be why she sometimes seems to lack common social ideas. However, out of all of the members of the workshop, she has the most common sense. Nikki has a beautiful singing voice and came to Al-Revis to find a husband so she can save her vanishing race. In her ending, she and Vayne get married and take care of their children.

Roxis Rosenkrantz (ロクシス・ローゼンクライツ, Rokushisu Rōzenkuraitsu)

Voiced by: Daisuke Kishio

A cool, sarcastic transfer student who comes from a famous alchemist family, Roxis is a very diligent, hard worker. His words are very polite, even though he is an annoying student. His hobbies are studying and reading. He likes being alone, and has an air about him that distances himself from others. He sees Vayne as a rival, and dislikes him. In his ending, Vayne and Roxis are sparring partners; the loser of each round is forced to be the other's test subject for all sorts of experiments.

Pamela Ibis (パメラ・イービス, Pamera Ībisu)

Voiced by: Asuka Tanii

A ghost girl who lives in Al-Revis, Pamela is very soft and likes all cute things. She is a recurring character in the Atelier series having previously appeared in Atelier Judie, Atelier Viorate, Atelier Iris: Eternal Mana and Atelier Iris 3: Grand Phantasm. She decides to join Vayne's workshop, but as soon as she sees how bleak it looks, she begins to complain about being in such a plain environment. With no other choice, Vayne gathers the cute items that Pamela wants, and decorates the workshop with them. In her ending, Pamela leaves Al-Revis with Vayne (now a doctor) to travel with him from town to town, though she does not stop her habit of scaring people. Later she appears in Atelier Rorona: The Alchemist of Arland, Atelier Totori: The Adventurer of Arland, Atelier Meruru: The Apprentice of Arland, Trinity Universe and Atelier Sophie: The Alchemist of the Mysterious Book.

Anna Lemouri (アンナ・レムリ, Anna Remuri)

Voiced by: Ui Miyazaki

Anna is a very young girl who has already mastered swordsmanship at her young age. She is an underclassman of Vayne, but is more mature than she looks. She is strict, fastidious, and takes most things far too seriously. She jokes at the results of her occasional wild speculations. Once she is set on a path, she is unstoppable. In her ending, Vayne meets her for a duel only to find that she now uses both alchemy and swords as part of her fighting style so she will happily use bombs and poisons on him.

Muppy Oktavia Wonderchak VIII (ムーペ・オクタヴィア・ヴォンドラチェク8世, Mupe Okutavia Wondoracheku Hachi-sei)

Voiced by: Yūichi Nagashima

Muppy is a foreign exchange student from a faraway world. By a strange turn of events, he ends up learning alchemy with Vayne and his workshop friends. He wanders the school in a pot-like machine, so everyone thinks he is slightly strange. His true plan is world domination as he tends to have delusions of grandeur. In his ending, Vayne travels with him to his home planet and asks Vayne to become his queen.

Sulpher (サルファ, Sarufa)

Voiced by: Akio Ōtsuka

Sulpher is Vayne and Mana's companion who transforms into Vayne's weapon in combat. Sulpher normally takes on the form of an arm-mounted blade with a red eye, but can change his shape to perform other attacks. Sulpher is apathetic, rude, and seemingly unimpressed by everything. He traveled alongside Theofratus until the day he died, then became friends with Vayne. (He could talk with Vayne, but he now cannot since Vayne has lost his powers). In fact, Sulpher is not a Mana, he is a normal cat. Vayne is the Mana while Sulpher himself is the contractor, able to take the forms he does simply because Vayne wishes it.

Isolde Schelling (イソルテ・シェリング, Isorude Sheringu)

Voiced by: Ayako Kawasumi

A female teacher at the academy, Isolde is Theofratus' lover. She is less pleasant than the other teachers, often giving out more difficult assignments. She is a graduate of Al-Revis and was classmates with Zeppel. While Zeppel is the laid back teacher, Isolde is much more serious. She cares for Vayne while on the other hand hates him for killing Theofratus.

Zeppel Kriever (ゼップル・クライパー, Zeppuru Kuraibā)

Voiced by: Kazuhiko Inoue

Vayne's homeroom teacher, Zeppel is friendly to students and is a popular teacher. He found Vayne in the mountains and invited him to the academy. In Mana Khemia 2 he has become the principal of Al-Revis Academy

Tony Eisler (トニ・アイスラー, Toni Aisurā)

Voiced by: Mitsuaki Madono

An older student at the academy who is exclusively seen with Renee, Tony seems to be the less powerful of the two. He hates Gunnar with a passion, and considers him his rival. However, his attempts to defeat him, and the main party, are usually met by exasperation. ("Who are these people?" "We don't have time to play with you!") Gunnar tends to just ignore or make fun of him, and as the game progresses, it becomes obvious that he is much less evil than he originally appeared. He angers easily, which makes his speech deteriorate, and causes him to him make rash decisions. He is ordered by Isolde to watch over Vayne. He returns to the academy in Mana Khemia 2 to become a full-time teacher, if only to continue his grudge against Gunnar.

Renee Kearse (レーネ・キア, Rēne Kia)

Voiced by: Ai Nonaka

Renee, an older academy student is seen exclusively with Tony and goes along with his bothering Vayne, but it seems her heart is not really in it. Whenever Tony makes up 'schemes' to defeat Vayne's company, she will neither stop nor encourage him. She barely has any interests in anything, and tends to become bored quickly by all kinds of activity. She also seems to be very powerful in combat, as Tony asks her help to beat up Flay in the beginning of the game. (But she prefers to back off to avoid breaking her new nails, and Tony decides against fighting Flay alone). The fact that she is capable of summoning the Mana who hates humans, Azure Flame Mana, may prove that she is a more formidable battler than she appears. Still, she will only fight seriously occasionally, so that she is not much of a threat to Vayne and the others.

Bernard Tieck (ベルンハルト・ティーク, Berunharuto Tīku)

Voiced by: Naomi Kusumi

Tieck is the academy's principal, and a jovial man who is nice to all students. He is also a great cook.

Ernentraud Karnap (エルメントラウト・カルナップ, Erumentorauto Karunappu)

Voiced by: Yukari Hishizu

The academy's vice-principal. She is very strict, and bullies the principal. She is also hopeless at baking.

Melanie Ruthers (メルヒス・ロイティエール, Meruhisu Roidiēru)

Voiced by: Rina Sato

Melanie is the academy's nurse and runs the infirmary and sells a variety of healing products. She enjoys teasing Vayne and his friends.

Cardinand Lorryale (Lorr) (カルダディイロルアレ (ロル), Karudadī Roruare (Roru))

Voiced by: Ryuuta Iguchi

Lorr is the academy's combat and tactics trainer. He is a beastman like Nikki.