Margaret Faul

Margaret M. Faul is an Irish / American chemist and executive who has won multiple awards for innovations in process chemistry.

Margaret M. Faul, Ph.D.
CitizenshipIrish
Alma materUniversity College Dublin, Harvard University
Known forGreen chemistry, process science
Scientific career
Thesis (1992)
Doctoral advisorDavid A. Evans

Background

Faul received her undergraduate degrees from University College, Dublin before embarking on doctoral studies with Professor David A. Evans at Harvard. Her studies focused mostly on metal-catalyzed nitrene transfer reactions[1] to produce aziridines, strained nitrogen precursors valued as pharmaceutical intermediates. Faul introduced multiple new wrinkles into this chemistry, including using chiral copper(I) catalysts[2] to produce enantiomerically-enriched aziridines, and using a variety of different nitrene sources for the transfer.

Research

Faul joined the process chemistry group at Eli Lilly in 1993, and joined Amgen's process group in 2003, rising eventually to its Executive Director. According to a biosketch at Organic Syntheses, Faul has expertise in Good Manufacturing Process scale-up of both chemical and biological therapeutics, and coordinates groups of external partners through licensing, regulatory, and program development issues.[3] She attributes much of Amgen's success in this area to early adoption of new technologies, such as supercritical carbon dioxide purification and ultra-high performance liquid chromatography (uPLC).[4]

Volunteer work

Faul is an Editorial Board member at Thieme journal Science of Synthesis.[5] She has served as the Chair of the Enabling Technologies Consortium.[6][7]

Awards and honors
  • 2019 - Fellow of the American Chemical Society (ACS)[8]
  • 2019 - Inaugural Margaret M. Faul Women in Chemistry Award, Thieme Publishers[9]
  • 2018 - Earl B. Barnes award for Chemical Research Management, ACS[10]
  • 2017 - Accepted the Presidential Green Chemistry Challenge award on behalf of Amgen Process[11]
  • 1986 - Hugh Ryan Memorial Medal, UCD

References
  1. Evans, David A.; Bilodeau, Mark T.; Faul, Margaret M. (April 1994). "Development of the Copper-Catalyzed Olefin Aziridination Reaction". Journal of the American Chemical Society. 116 (7): 2742–2753. doi:10.1021/ja00086a007. ISSN 0002-7863.
  2. Evans, David A.; Faul, Margaret M.; Bilodeau, Mark T.; Anderson, Benjamin A.; Barnes, David M. (June 1993). "Bis(oxazoline)-copper complexes as chiral catalysts for the enantioselective aziridination of olefins". Journal of the American Chemical Society. 115 (12): 5328–5329. doi:10.1021/ja00065a068. ISSN 0002-7863.
  3. Faul, Margaret (2017). "Faul biosketch" (PDF). Organic Syntheses. Archived from the original (PDF) on 2017-07-21. Retrieved 2018-11-19.
  4. Patel, Prachi (2017-02-10). "A Conversation with Margaret Faul". ACS Central Science. 3 (2): 141–142. doi:10.1021/acscentsci.7b00050. ISSN 2374-7943. PMC 5324089. PMID 28280781.
  5. "Science of Synthesis Editorial Board - Thieme Chemistry - Georg Thieme Verlag". Thieme. Retrieved 2018-11-19.
  6. "Portrait of Dr. Margaret Faul - Thieme Chemistry - Georg Thieme Verlag KG". Thieme. Retrieved 2018-11-19.
  7. "Working Groups". ETC. Archived from the original on 2018-11-19. Retrieved 2018-11-19.
  8. "2019 ACS Fellows". American Chemical Society. Retrieved 2019-08-12.
  9. "Women in Chemistry Award - Thieme Chemistry - Georg Thieme Verlag KG". Thieme. Retrieved 2018-11-19.
  10. "Earle B. Barnes Award for Leadership in Chemical Research Management: Margaret M. Faul | January 8, 2018 Issue - Vol. 96 Issue 2 | Chemical & Engineering News". cen.acs.org. Retrieved 2018-11-19.
  11. "Amgen Wins the 2017 Green Chemistry Challenge Award". www.amgen.com. Retrieved 2018-11-19.
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