Martin Scorsese and Robert De Niro

In 1973, De Niro had been praised for his role in Bang the Drum Slowly while Scorsese had been working as an editor on the movie Woodstock. The same year, Scorsese and De Niro collaborated for the first time on the gangster film Mean Streets. Scorsese had been taught that entertaining films can be shot with little money by Roger Corman, who had helped prepare Scorsese for the difficulties of making Mean Streets.

The film, about a small-time gangster living in Little Italy, was a success and in 1997 was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant". It was also listed in a BBC poll as the 93rd best American film.[3]

Hugely popular, the film was directed by Scorsese and starred De Niro. It caused controversy but still had a huge cultural impact. The line "You talkin' to me?", spoken by De Niro's character Travis Bickle, has become one of the most famous lines in film history. Scorsese makes a credited cameo in this film as a passenger of Bickle's who plans to kill his wife.

In 1977, De Niro starred in Scorsese's New York, New York, a musical-drama film. It was a musical tribute, featuring new songs by John Kander and Fred Ebb as well as standards, to Scorsese's home town of New York City, and starred De Niro and Liza Minnelli as a pair of musicians and lovers. During filming, the married Scorsese became romantically involved with Minnelli and began heavily using cocaine and other hard narcotics. At the time Andy Warhol wrote in his diary that Minnelli and Scorsese showed up at the door of a famous fashion designer demanding: "Give me every drug you've got".

Made after Taxi Driver, the film was a box-office failure. Its budget was $14 million, a large figure at the time, but it grossed only $13 million at the box-office and its disappointing reception and his breakup with Minnelli drove Scorsese into depression and further into drug abuse.[4]

In 1980, Scorsese made Raging Bull, a film starring De Niro as an emotionally self-destructive boxer, the film following his journey through life, as the violence and temper that leads him to the top in the ring destroys his life outside it. De Niro won an Oscar for his role and Scorsese was nominated as best director; the film collected 6 other Oscar nominations as well.

The film has been considered one of the greatest films of all time, and was chosen as the best sports film ever by the American Film Institute.[5]

In 1982, Scorsese and De Niro made their first film to feature several comedic elements, while still being connected with the crime genre. The film follows aspiring comic Rupert Pupkin (De Niro), who wants to achieve success in showbiz, by resorting to stalking his idol, a late night talk show host who craves privacy. The film won a BAFTA for Best Original Screenplay, and was nominated for four other BAFTAs, including Best Direction for Scorsese and Best Actor for De Niro.

The film was generally praised by critics but did not perform well in the United States. Scorsese suggested the film "...maybe wasn't so well received because it gave off an aura of something that people didn't want to look at or know."[6]

De Niro and Scorsese collaborated again in 1990 on Goodfellas, which also starred Ray Liotta and Joe Pesci. The film follows Henry Hill (Liotta) as he and his friends work their way up through the mob. Goodfellas was incredibly successful and won five BAFTAs. It was beaten in most categories at the Oscars by Dances with Wolves, but achieved universal acclaim with critics[7] and is considered one of the greatest films of all time.

In 2005, it was named the greatest film of all time by British magazine Total Film.[8]

1991's Cape Fear sees De Niro star as a convicted rapist, released from prison after serving a 14-year sentence, who stalks the family of the defense lawyer who represented him but deliberately suppressed evidence that would have acquitted him. It is a remake of the 1962 film of the same name. The film received generally favorable reviews[9] and was nominated for two Oscars and two BAFTAs. Steven Spielberg was an executive producer.

1995 saw De Niro and Scorsese reunite with Pesci after 1990's Goodfellas for Casino. The film revolved around greed, deception, money, power, and murder that occur between two mobster best friends and a trophy wife over a gambling empire. The film received favorable reviews, with Michael Wilmington of the Chicago Tribune saying "You can't praise highly enough the contributions of the ensemble – De Niro and Pesci especially – but it's Scorsese's triumph." Sharon Stone received an Oscar nomination for her role.

Scorsese and De Niro collaborated for the first time in two decades for The Audition, a 2015 short film that served as a promotional piece for casinos Studio City in Macau, China and City of Dreams in Manila, Philippines. The short united Scorsese's two muses, De Niro and Leonardo DiCaprio, for the first time on film under his direction.[10]

An epic crime film directed by Martin Scorsese and written by Steven Zaillian, based on the book I Heard You Paint Houses by Charles Brandt. The film stars Robert De Niro as Frank Sheeran, a labor union leader and alleged hitman for the Bufalino crime family, Al Pacino as Jimmy Hoffa, and Joe Pesci as Russell Bufalino. The film marks the first time Pacino has been directed by Scorsese.[11]

In October 2018, it was announced that DiCaprio and Scorsese were re-teaming for a film adaptation of David Grann's Killers of the Flower Moon, about the Osage Indian murders. In summer 2019, it was confirmed that Robert De Niro will star alongside DiCaprio. Shooting has been postponed from its original start date due to the COVID-19 pandemic.[12]