Matthew Hurles

Education

Hurles was educated at the University of Oxford where he was awarded a Bachelor of Arts degree in Biochemistry. He completed his PhD in 1999 on the genetics of the Y chromosome at the University of Leicester supervised by Mark Jobling[2][7][8]

Research and career

Hurles research investigates the causes and consequences of new mutations as DNA is passed from one generation to the next.[3] He is best known for his work on characterizing the extent and impact of structural variation in the human genome and on deciphering the genetic architecture of severe neurodevelopmental disorders.[3]

Hurles group has used large-scale genomic studies to highlight the predominant role that new mutations of many different types play in causing diverse developmental disorders and has led to the discovery of tens of previously unrecognised genetic diseases.[3][9][10][11]

Awards and honours

Hurles was elected a Fellow of the Royal Society (FRS) in 2019.[3] He is also a Fellow of the Academy of Medical Sciences (FMedSci) and was awarded the Crick Medal and Lecture in 2013.[3]

References
  1. Anon (2018). "Matthew Hurles: Congenica Ltd". companieshouse.gov.uk. London: Companies House. Archived from the original on 2019-10-25.
  2. Hurles, Matthew (1999). Mutation and variability of the human Y chromosome. le.ac.uk (PhD thesis). University of Leicester. hdl:2381/30320. OCLC 505103676. EThOS uk.bl.ethos.696631.
  3. Anon (2019). "Professor Matthew Hurles FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 2019-04-24. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  4. Matthew Hurles publications indexed by Google Scholar
  5. Matthew Hurles publications indexed by the Scopus bibliographic database. (subscription required)
  6. Matthew Hurles publications from Europe PubMed Central
  7. Hurles, Matthew E.; Veitia, Reiner; Arroyo, Eduardo; Armenteros, Manuel; Bertranpetit, Jaume; Pérez-Lezaun, Anna; Bosch, Elena; Shlumukova, Maria; Cambon-Thomsen, Anne; McElreavey, Ken; López de Munain, Adolfo; Röhl, Arne; Wilson, Ian J.; Singh, Lalji; Pandya, Arpita; Santos, Fabrício R.; Tyler-Smith, Chris; Jobling, Mark A. (1999). "Recent Male-Mediated Gene Flow over a Linguistic Barrier in Iberia, Suggested by Analysis of a Y-Chromosomal DNA Polymorphism". The American Journal of Human Genetics. 65 (5): 1437–1448. doi:10.1086/302617. ISSN 0002-9297. PMC 1288297. PMID 10521311.
  8. Hurles, Matthew E.; Irven, Catherine; Nicholson, Jayne; Taylor, Paul G.; Santos, Fabricio R.; Loughlin, John; Jobling, Mark A.; Sykes, Bryan C. (1998). "European Y-Chromosomal Lineages in Polynesians: A Contrast to the Population Structure Revealed by mtDNA". The American Journal of Human Genetics. 63 (6): 1793–1806. doi:10.1086/302147. ISSN 0002-9297. PMC 1377652. PMID 9837833.
  9. The 1000 Genomes Project Consortium (2010). "A map of human genome variation from population-scale sequencing". Nature. 467 (7319): 1061–1073. doi:10.1038/nature09534. ISSN 0028-0836. PMC 3042601. PMID 20981092.
  10. The 1000 Genomes Project Consortium (2012). "An integrated map of genetic variation from 1,092 human genomes". Nature. 491 (7422): 56–65. doi:10.1038/nature11632. ISSN 0028-0836. PMC 3498066. PMID 23128226.
  11. Redon, Richard; Ishikawa, Shumpei; Fitch, Karen R.; Feuk, Lars; Perry, George H.; Andrews, T. Daniel; Fiegler, Heike; Shapero, Michael H.; Carson, Andrew R.; Chen, Wenwei; Cho, Eun Kyung; Dallaire, Stephanie; Freeman, Jennifer L.; González, Juan R.; Gratacòs, Mònica; Huang, Jing; Kalaitzopoulos, Dimitrios; Komura, Daisuke; MacDonald, Jeffrey R.; Marshall, Christian R.; Mei, Rui; Montgomery, Lyndal; Nishimura, Kunihiro; Okamura, Kohji; Shen, Fan; Somerville, Martin J.; Tchinda, Joelle; Valsesia, Armand; Woodwark, Cara; Yang, Fengtang; Zhang, Junjun; Zerjal, Tatiana; Zhang, Jane; Armengol, Lluis; Conrad, Donald F.; Estivill, Xavier; Tyler-Smith, Chris; Carter, Nigel P.; Aburatani, Hiroyuki; Lee, Charles; Jones, Keith W.; Scherer, Stephen W.; Hurles, Matthew E. (2006). "Global variation in copy number in the human genome". Nature. 444 (7118): 444–454. doi:10.1038/nature05329. ISSN 0028-0836. PMC 2669898. PMID 17122850.
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