Michael Elowitz

Michael B. Elowitz is a biologist and professor of Biology, Bioengineering, and Applied Physics at the California Institute of Technology,[1][2][3] and investigator at the Howard Hughes Medical Institute.[4] In 2007 he was the recipient of the Genius grant, better known as the MacArthur Fellows Program for the design of a synthetic gene regulatory network, the Repressilator, which helped initiate the field of synthetic biology.[5] In addition, he showed, for the first time, how inherently random effects, or 'noise', in gene expression could be detected and quantified in living cells,[6] leading to a growing recognition of the many roles that noise plays in living cells. His work in Synthetic Biology and Noise represent two foundations of the field of Systems Biology.

Michael Elowitz
NationalityAmerican
Alma materUniversity of California, Berkeley Princeton University
AwardsMacArthur Fellows Program
Scientific career
FieldsBiology
InstitutionsCalifornia Institute of Technology;
Howard Hughes Medical Institute

Career

His laboratory studies the dynamics of genetic circuits in individual living cells using synthetic biology, time-lapse microscopy, and mathematical modeling, with a particular focus on the way in which cells make use of noise to implement behaviors that would be difficult or impossible without it. Recently, his lab has expanded their approaches beyond bacteria to include eukaryotic and mammalian cells.[7]

Life

Elowitz grew up in Los Angeles, California, where he attended the humanities magnet at Alexander Hamilton High School (Los Angeles). He studied Physics and graduated with a B.A. from the University of California, Berkeley in 1992,[8] and from Princeton University with a Ph.D. in 1999.[9] In 1997–1998, he spent one year at the European Molecular Biology Laboratory at Heidelberg. Afterwards, he was a postdoctoral fellow at the Rockefeller University in New York City.

While working as a graduate student at Princeton he co-authored songs such as Sunday at the Lab[10] with Uri Alon.

Awards

Peer-reviewed publications
  • Li P, Markson JS, Wang S, Chen S, Vachharajan V, Elowitz MB, "Morphogen gradient reconstitution reveals Hedgehog pathway design principles," Science (2018).[18]
  • Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB, "Dynamics of epigenetic regulation at the single-cell level," Science (2016).[19]
  • Lin Y, Sohn CH, Dalal CK, Cai L, Elowitz MB, Combinatorial gene regulation by modulation of relative pulse timing, Nature, 2015[20]
  • Suel, G. M.; Kulkarni, R. P.; Dworkin, J.; Garcia-Ojalvo, J.; Elowitz, M. B. (2007). "Tunability and Noise Dependence in Differentiation Dynamics" (PDF). Science. 315 (5819): 1716–1719. doi:10.1126/science.1137455. PMID 17379809.
  • Süel, G. R. M.; Garcia-Ojalvo, J.; Liberman, L. M.; Elowitz, M. B. (2006). "An excitable gene regulatory circuit induces transient cellular differentiation". Nature. 440 (7083): 545–550. doi:10.1038/nature04588. PMID 16554821.
  • Sprinzak, D.; Elowitz, M. B. (2005). "Reconstruction of genetic circuits". Nature. 438 (7067): 443–448. doi:10.1038/nature04335. PMID 16306982.
  • Rosenfeld, N.; Young, J. W.; Alon, U.; Swain, P. S.; Elowitz, M. B. (2005). "Gene Regulation at the Single-Cell Level" (PDF). Science. 307 (5717): 1962–1965. doi:10.1126/science.1106914. PMID 15790856.
  • Elowitz, M. B.; Levine, A. J.; Siggia, E. D.; Swain, P. S. (2002). "Stochastic Gene Expression in a Single Cell". Science. 297 (5584): 1183–1186. doi:10.1126/science.1070919. PMID 12183631.
  • Guet, C. A. ;L. C.; Elowitz, M. B.; Hsing, W.; Leibler, S. (2002). "Combinatorial Synthesis of Genetic Networks". Science. 296 (5572): 1466–1470. doi:10.1126/science.1067407. PMID 12029133.
  • Elowitz, M. B.; Leibler, S. (2000). "A synthetic oscillatory network of transcriptional regulators". Nature. 403 (6767): 335–338. doi:10.1038/35002125. PMID 10659856.
  • Rosenfeld, N.; Elowitz, M. B.; Alon, U. (2002). "Negative autoregulation speeds the response times of transcription networks". Journal of Molecular Biology. 323 (5): 785–793. doi:10.1016/S0022-2836(02)00994-4. PMID 12417193.
  • Elowitz, M. B.; Surette, M. G.; Wolf, P. E.; Stock, J.; Leibler, S. (1997). "Photoactivation turns green fluorescent protein red". Current Biology. 7 (10): 809–812. doi:10.1016/S0960-9822(06)00342-3. PMID 9368766.
  • Levine, J. H.; Fontes, M. E.; Dworkin, J.; Elowitz, M. B. (2012). Laub, Michael (ed.). "Pulsed Feedback Defers Cellular Differentiation". PLoS Biology. 10 (1): e1001252. doi:10.1371/journal.pbio.1001252. PMC 3269414. PMID 22303282.
  • Locke, J. C. W.; Young, J. W.; Fontes, M.; Jimenez, M. J. H.; Elowitz, M. B. (2011). "Stochastic Pulse Regulation in Bacterial Stress Response". Science. 334 (6054): 366–369. doi:10.1126/science.1208144. PMC 4100694. PMID 21979936.

References
  1. "The Elowitz Lab [Caltech]". www.elowitz.caltech.edu.
  2. "Archived copy". Archived from the original on 24 June 2010. Retrieved 27 March 2010.CS1 maint: archived copy as title (link)
  3. "Caltech Applied Physics - Not Found". www.aph.caltech.edu.
  4. "Michael B. Elowitz, PhD - HHMI.org".
  5. "Ten years of synergy". Nature. 463 (7279): 269–270. January 1, 2010. doi:10.1038/463269b. PMID 20090703.
  6. "Database of Cell Signaling and Virtual Journal - Science Signaling". stke.sciencemag.org.
  7. "Gene Circuit Dynamics in Regulation and Differentiation", Howard Hughes Medical Institute
  8. Applied Physics at Caltech, retrieved March 9, 2010
  9. "Searle Scholars Program : 2007 News Archive". www.searlescholars.net.
  10. Sunday at the Lab performed by Uri Alon
  11. "2011 HFSP Nakasone Award goes to Michael Elowitz - Human Frontier Science Program". www.hfsp.org.
  12. Presidential Early Career Award for Scientists and Engineers
  13. "20 Best Brains Under 40 - DiscoverMagazine.com".
  14. "Archived copy". Archived from the original on March 15, 2012. Retrieved May 13, 2019.CS1 maint: archived copy as title (link)
  15. "Elowitz, Michael - The David and Lucile Packard Foundation".
  16. TR35 winners
  17. "Archived copy". Archived from the original on 25 July 2011. Retrieved 27 March 2010.CS1 maint: archived copy as title (link)
  18. Li, Pulin; Markson, Joseph S.; Wang, Sheng; Chen, Siheng; Vachharajani, Vipul; Elowitz, Michael B. (April 5, 2018). "Morphogen gradient reconstitution reveals Hedgehog pathway design principles". Science. 360 (6388): 543–548. doi:10.1126/science.aao0645. ISSN 0036-8075. PMC 6516753. PMID 29622726.
  19. Bintu, Lacramioara; Yong, John; Antebi, Yaron E.; McCue, Kayla; Kazuki, Yasuhiro; Uno, Narumi; Oshimura, Mitsuo; Elowitz, Michael B. (February 12, 2016). "Dynamics of epigenetic regulation at the single-cell level". Science. 351 (6274): 720–724. doi:10.1126/science.aab2956. ISSN 0036-8075. PMC 5108652. PMID 26912859.
  20. Lin, Yihan; Sohn, Chang Ho; Dalal, Chiraj K.; Cai, Long; Elowitz, Michael B. (2015). "Combinatorial gene regulation by modulation of relative pulse timing". Nature. 527 (7576): 54–58. doi:10.1038/nature15710. PMC 4870307. PMID 26466562.
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