Michael Freeling

Michael Freeling is an American geneticist and plant biologist. He is currently a professor in the Department of Plant and Microbial Biology at the University of California. He is known for early work on maize anaerobic metabolism, developmental genetics of the maize ligule, proposing the grasses as a single genetic system model with Jeffrey Bennetzen, and the discovery of biased gene retention following whole genome duplications in plants. In 1994 Freeling was elected to the National Academy of Sciences.[1] In 2017 he was awarded the McClintock Prize for Plant Genetics and Genome Studies.[2]

Michael Freeling
Born(1945-01-14)January 14, 1945
Fort Wayne, Indiana
NationalityUnited States
Alma materUniversity of Indiana
AwardsMcClintock Prize 2017
Scientific career
FieldsGenetics, Plant Biology
InstitutionsUniversity of California, Berkeley
Thesis (1973)
Doctoral advisorDrew Schwartz
Websitehttp://freelinglab.berkeley.edu/

Education and Career

Freeling was born in Fort Wayne, Indiana in 1945. He attended the University of Oregon graduating with an A.B. in 1968. He then join Drew Schwatz's research group at the University of Indiana where he also worked with Marcus Rhoades. Completing his PhD in 1973 he was hired by the University of California, Berkeley as an Assistant Professor of Genetics. Freeling was promoted to Associate Professor in 1979, and to full professor in 1984.[3] In 1980 he was selected as a Guggenheim Fellow which supported his time as a visiting professor at the Rothamsted Experimental Station, in England[3][4]

Research

Abiotic Stress

In the 1980 Freeling found an early response to anaerobic conditions is the suppression of the translation of mRNAs. After several hours a small a small group of anaerobic peptides including alcohol dehydrogenases are produced instead.[5] He also found that the cytoplasmic acidosis was a good predictor of how poorly plants can tolerate flooding stress.[6]

Comparative Genomics

Freeling and Jeffrey Bennetzen proposed the model of the grasses as a single genetic system.[7] Freeling developed tools for identifying conserved non-coding sequences in plant genomes and has played a role in sequencing the genomes of papaya, sorghum, banana, Brassica rapa, pineapple and strawberry.[8]

Freeling's research group also studies ancient whole genome duplications. He identified biased gene loss between duplicated regions of the arabidopsis genome.[9] In maize they found that genes on the copy of the genome had lost more genes tended to be expressed at lower levels than duplicate copies of the same genes on the copy of the genome which had lost fewer genes.[10]

Trainees

Between 1973 and 2014 Freeling was the mentor for 27 PhD students and 49 postdocs, including three who went on to also be elected to the National Academy of Sciences.[11]

References
  1. http://www.nasonline.org/member-directory/members/66122.html
  2. https://plantandmicrobiology.berkeley.edu/news/freeling-awarded-mcclintock-prize
  3. http://freelinglab.berkeley.edu/MF_CV8-2015.htm
  4. https://www.gf.org/fellows/all-fellows/michael-freeling/
  5. Sachs, Martin M., Michael Freeling, and Ronald Okimoto. "The anaerobic proteins of maize." Cell 20.3 (1980): 761-767. doi: https://doi.org/10.1016/0092-8674(80)90322-0
  6. Roberts, J. K., Callis, J., Jardetzky, O., Walbot, V., & Freeling, M. (1984). Cytoplasmic acidosis as a determinant of flooding intolerance in plants. Proceedings of the National Academy of Sciences, 81(19), 6029-6033. doi: https://doi.org/10.1073/pnas.81.19.6029
  7. Bennetzin, J. L., & Freeling, M. (1993). Grasses as a single genetic system: genome composition, collinearity and compatibility. Trends in Genetics, 9(8), 259-261. doi: https://doi.org/10.1016/0168-9525(93)90001-X
  8. https://scholar.google.com/citations?hl=en&user=aKnu9s0AAAAJ
  9. Thomas, B. C., Pedersen, B., & Freeling, M. (2006). Following tetraploidy in an Arabidopsis ancestor, genes were removed preferentially from one homeolog leaving clusters enriched in dose-sensitive genes. Genome research, 16(7), 934-946. https://doi.org/10.1101/gr.4708406
  10. Schnable, J. C., Springer, N. M., & Freeling, M. (2011). Differentiation of the maize subgenomes by genome dominance and both ancient and ongoing gene loss. Proceedings of the National Academy of Sciences, 108(10), 4069-4074. doi: https://doi.org/10.1073/pnas.1101368108
  11. http://freelinglab.berkeley.edu/historical/FreelingLab1973-2014.htm
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