Mir-663 microRNA precursor family
In molecular biology mir-663 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-663 | |
|---|---|
| Identifiers | |
| Symbol | mir-663 |
| Rfam | RF00957 |
| miRBase family | MIPF0000462 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Gastric cancer suppression
miR-663 has been identified as a possible suppressor of tumour growth, with its levels downregulated in human gastric cancer (GC) cell lines. miR-663 introduction into the two human GC cell lines BGC823 and SNU5 induces morphology changes and suppresses cell proliferation.[1] Transfection with miR-663 also sees a resultant upregulation of cyclin B.
miR-155 upregulation and other molecular targets
Resveratrol, a natural phenol and antioxidant, upregulates miR-663 in human THP-1 monocytic cells, human blood monocytes and MCF7 brest cancer cells.[2] Endogenous activator protein-1 (AP-1) activity is decreased by miR-663 and there is additional impaired lipopolysaccharide upregulation. miR-663 directly targets JunD and JunB transcripts, and alters AP-1 upregulation through this. It is further involved in the impaired lipolysaccharide upregulation of miR-155 by resveratrol.[3] miR-663 also directly targets EEF1A2, transaltion elongation factor and well-known protooncogene.[2][4]
See also
References
- Pan J, Hu H, Zhou Z, Sun L, Peng L, Yu L, Sun L, Liu J, Yang Z, Ran Y (July 2010). "Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells". Oncology Reports. 24 (1): 105–12. doi:10.3892/or_00000834. PMID 20514450.
- Vislovukh A, Kratassiouk G, Porto E, Gralievska N, Beldiman C, Pinna G, El'skaya A, Harel-Bellan A, Negrutskii B, Groisman I (June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744". British Journal of Cancer. 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMC 3681015. PMID 23695020.
- Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM (September 2010). "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD". Carcinogenesis. 31 (9): 1561–6. doi:10.1093/carcin/bgq143. PMC 4647642. PMID 20622002.
- Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH, Collins C, Gray JW, Diebold J, Demetrick DJ, Lee JM (July 2002). "Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer". Nature Genetics. 31 (3): 301–5. doi:10.1038/ng904. PMID 12053177. S2CID 37997742.
Further reading
- Liang P, Lv C, Jiang B, Long X, Zhang P, Zhang M, Xie T, Huang X (June 2012). "MicroRNA profiling in denatured dermis of deep burn patients". Burns. 38 (4): 534–40. doi:10.1016/j.burns.2011.10.014. PMID 22360957.
- Lu J, Kwan BC, Lai FM, Tam LS, Li EK, Chow KM, Wang G, Li PK, Szeto CC (May 2012). "Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis". Nephrology. 17 (4): 346–51. doi:10.1111/j.1440-1797.2012.01573.x. PMID 22295894.
- Yi C, Wang Q, Wang L, Huang Y, Li L, Liu L, Zhou X, Xie G, Kang T, Wang H, Zeng M, Ma J, Zeng Y, Yun JP (October 2012). "MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma". Oncogene. 31 (41): 4421–33. doi:10.1038/onc.2011.629. PMID 22249270.
- Yang Y, Wang LL, Li YH, Gao XN, Liu Y, Yu L (February 2012). "Effect of CpG island methylation on microRNA expression in the k-562 cell line". Biochemical Genetics. 50 (1–2): 122–34. doi:10.1007/s10528-011-9478-9. PMID 22089542. S2CID 16736093.
- Marques FZ, Campain AE, Tomaszewski M, Zukowska-Szczechowska E, Yang YH, Charchar FJ, Morris BJ (December 2011). "Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs". Hypertension. 58 (6): 1093–8. doi:10.1161/HYPERTENSIONAHA.111.180729. PMID 22042811.
- Borgan E, Navon R, Vollan HK, Schlichting E, Sauer T, Yakhini Z, Lingjærde OC, Sørlie T, Børresen-Dale AL (December 2011). "Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue". Molecular Oncology. 5 (6): 564–76. doi:10.1016/j.molonc.2011.08.004. PMC 5528325. PMID 21917534.
- Tili E, Michaille JJ (2011). "Resveratrol, MicroRNAs, Inflammation, and Cancer". Journal of Nucleic Acids. 2011: 102431. doi:10.4061/2011/102431. PMC 3154569. PMID 21845215.
- Yang Y, Wang LL, Li YH, Gao XN, Yu L (April 2011). "[Expression level of miRNA-663 in different leukemic cell lines and its biological function]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 19 (2): 279–83. PMID 21518471.
- Jian P, Li ZW, Fang TY, Jian W, Zhuan Z, Mei LX, Yan WS, Jian N (April 2011). "Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663". Journal of Hematology & Oncology. 4: 20. doi:10.1186/1756-8722-4-20. PMC 3094392. PMID 21518431.
- Ni CW, Qiu H, Jo H (May 2011). "MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells". American Journal of Physiology. Heart and Circulatory Physiology. 300 (5): H1762-9. doi:10.1152/ajpheart.00829.2010. PMC 3094086. PMID 21378144.
- Potapova A, Albat C, Hasemeier B, Haeussler K, Lamprecht S, Suerbaum S, Kreipe H, Lehmann U (January 2011). "Systematic cross-validation of 454 sequencing and pyrosequencing for the exact quantification of DNA methylation patterns with single CpG resolution". BMC Biotechnology. 11: 6. doi:10.1186/1472-6750-11-6. PMC 3032674. PMID 21235780.
- Liu ZY, Zhang GL, Wang MM, Xiong YN, Cui HQ (2011). "MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation". Asian Pacific Journal of Cancer Prevention. 12 (11): 2819–23. PMID 22393947.
- Dreher A, Rossing M, Kaczkowski B, Nielsen FC, Norrild B (December 2010). "Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR". Biochemical and Biophysical Research Communications. 403 (3–4): 357–62. doi:10.1016/j.bbrc.2010.11.035. PMID 21078297.
- Tili E, Michaille JJ, Alder H, Volinia S, Delmas D, Latruffe N, Croce CM (December 2010). "Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells". Biochemical Pharmacology. 80 (12): 2057–65. doi:10.1016/j.bcp.2010.07.003. PMC 3918904. PMID 20637737.
- Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM (September 2010). "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD". Carcinogenesis. 31 (9): 1561–6. doi:10.1093/carcin/bgq143. PMC 4647642. PMID 20622002.
- Marasa BS, Srikantan S, Martindale JL, Kim MM, Lee EK, Gorospe M, Abdelmohsen K (June 2010). "MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence". Aging. 2 (6): 333–43. doi:10.18632/aging.100159. PMC 2919253. PMID 20606251.
- Te JL, Dozmorov IM, Guthridge JM, Nguyen KL, Cavett JW, Kelly JA, Bruner GR, Harley JB, Ojwang JO (May 2010). Means T (ed.). "Identification of unique microRNA signature associated with lupus nephritis". PLOS ONE. 5 (5): e10344. doi:10.1371/journal.pone.0010344. PMC 2867940. PMID 20485490.
- Buratti E, De Conti L, Stuani C, Romano M, Baralle M, Baralle F (May 2010). "Nuclear factor TDP-43 can affect selected microRNA levels". The FEBS Journal. 277 (10): 2268–81. doi:10.1111/j.1742-4658.2010.07643.x. PMID 20423455.
- Maes OC, Sarojini H, Wang E (October 2009). "Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts". Journal of Cellular Physiology. 221 (1): 109–19. doi:10.1002/jcp.21834. PMID 19475566.
- Pizzimenti S, Ferracin M, Sabbioni S, Toaldo C, Pettazzoni P, Dianzani MU, Negrini M, Barrera G (January 2009). "MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation". Free Radical Biology & Medicine. 46 (2): 282–8. doi:10.1016/j.freeradbiomed.2008.10.035. PMID 19022373.
- Lehmann U, Hasemeier B, Römermann D, Müller M, Länger F, Kreipe H (2007). "[Epigenetic inactivation of microRNA genes in mammary carcinoma]". Verhandlungen der Deutschen Gesellschaft für Pathologie. 91: 214–20. PMID 18314617.
- Lehmann U, Hasemeier B, Christgen M, Müller M, Römermann D, Länger F, Kreipe H (January 2008). "Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer". The Journal of Pathology. 214 (1): 17–24. doi:10.1002/path.2251. PMID 17948228.
External links
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