Mockingbird Lane

• Jerry O'Connell as Herman Munster, a man made from parts of other people. Unlike Herman in the original series, Herman looks human except for some very obvious scars (in keeping with many modern-day interpretations of the Frankenstein Monster, upon which Herman was based). He is very intelligent but has a sensitive heart. He loves his family, and to a lesser extent his father-in-law. His heart, the last remaining part from his original body, is dying because he "loves too hard".
• Portia de Rossi as Lily Munster (née Dracula) the elegant matriarch of the Munster family and a vampire. Unlike her father, Lily tries not to attack or manipulate humans. She loves her family very much and only wants them safe.
• Charity Wakefield as Marilyn Munster, Lily's niece, is a normal human and has no monster-like attributes. She is considered the oddball of the family because she looks and acts normal. Her mother tried to eat her, but Grandpa talked her out of it.
• Mason Cook as Eddie Munster, an apparently normal adolescent boy who does not initially know that he is a werewolf. When Herman and Lily are forced to break this news to him, they obtain for him a pet dragon to watch over him during his transformations.
• Eddie Izzard as Grandpa, Lily's father, also a vampire. He likes to act like he is the head of the family. He enjoys making wisecracks at Herman's expense. This version of Grandpa is much darker than the character in the original series, exhibiting predatory behavior and a fondness for murder and mind control.

• Cheyenne Jackson as Scoutmaster Steve, a widower and leader of Eddie's scout troop who becomes smitten with Lily. Grandpa plots to kill him so he can feed off his blood and replace Herman's heart; despite Herman's clear protests. Grandpa gets his way when Steve dies in an accident.
• Beth Grant as Marianne Marie Beetle, the paraplegic busybody neighbor who takes a very keen interest in the strange new family next door. This character previously appeared in episodes of Wonderfalls and Pushing Daisies.
• Guy Perry as Werewolf
• John Kassir as Tim, Marie's husband.

NBC confirmed ordering the pilot episode in November 2011[4] and announced in January 2012 that it would be called Mockingbird Lane, a reference to the Munster family address at 1313 Mockingbird Lane.[5] The costumes and make-up for the characters were heavily toned down to have them more closely resemble humans.[6]

On March 20, 2012, former The Riches star Eddie Izzard was announced by NBC as "Grandpa", the first of the prospective series' main roles to be cast.[7][8] British actress Charity Wakefield joined the cast, playing Marilyn Munster, Lily's niece, and Spy Kids: All the Time in the World actor Mason Cook joined as Eddie Munster.[9] On June 4, 2012, it was announced that Jerry O'Connell had been cast as family patriarch Herman Munster who series writer-producer Bryan Fuller describes as "essentially a zombie in a constant state of decay."[10] On June 5, it was announced that Mariana Klaveno had been cast to play his wife Lily, contingent on her being released from her contract on Devious Maids.[11] However, on June 12, 2012, it was announced that Portia de Rossi would play the role.[12]