Montreal Cognitive Assessment

The Montreal Cognitive Assessment (MoCA) is a widely used screening assessment for detecting cognitive impairment.[1] It was created in 1996 by Ziad Nasreddine in Montreal, Quebec. It was validated in the setting of mild cognitive impairment, and has subsequently been adopted in numerous other settings clinically.

Montreal Cognitive Assessment
Purposedetects cognitive impairment

Format

The MoCA test is a one-page 30-point test administered in approximately 10 minutes.[2] The test and administration instructions are available for clinicians online. The test is available in 46 languages and dialects (as of 2017).

In this clock drawing task, the subject is asked to draw a clock with the hours and showing the time 2:30. Successive results show a deterioration of pattern processing ability in a subject as they progress from mild cognitive impairment (MCI) to severe Alzheimer's disease (AD).

The MoCA assesses several cognitive domains:

  • The short-term memory recall task (5 points) involves two learning trials of five nouns and delayed recall after approximately five minutes.
  • Visuospatial abilities are assessed using a clock-drawing task (3 points) and a three-dimensional cube copy (1 point).
  • Multiple aspects of executive functions are assessed using an alternation task adapted from the trail-making B task (1 point), a phonemic fluency task (1 point), and a two-item verbal abstraction task (2 points).
  • Attention, concentration, and working memory are evaluated using a sustained attention task (target detection using tapping; 1 point), a serial subtraction task (3 points), and digits forward and backward (1 point each).
  • Language is assessed using a three-item confrontation naming task with low-familiarity animals (lion, camel, rhinoceros; 3 points), repetition of two syntactically complex sentences (2 points), and the aforementioned fluency task.
  • Abstract reasoning is assessed using a describe the similarity task with 2 points being available.
  • Finally, orientation to time and place is evaluated by asking the subject for the date and the city in which the test is occurring (6 points).

Because MoCA is English specific, linguistic and cultural translations are made in order to adapt the test in other countries. Multiple cultural and linguistic variables may affect the norms of the MoCA across different countries and languages e.g. Swedish.[3] Several cut-off scores have been suggested across different languages to compensate for education level of the population, and several modifications were also necessary to accommodate certain linguistic and cultural differences across different languages/countries. However, not all versions have been validated.

Efficacy

MoCA test study

A MoCA test validation study by Nasreddine in 2005 showed that the MoCA was a promising tool for detecting Mild Cognitive Impairment (MCI) and Early Alzheimer's disease compared with the well-known Mini-Mental State Examination (MMSE).[4]

According to the validation study, the sensitivity and specificity of the MoCA for detecting MCI were 90% and 87% respectively, compared with 18% and 100% respectively for the MMSE. Subsequent studies in other settings were less promising, though generally superior to the MMSE.[5][6]

Other studies have tested the MoCA on patients with Alzheimer's disease.[7][8][9]

Recommendations

The National Institutes of Health and the Canadian Stroke Network recommended selected subsets of the MoCA for the detection of vascular cognitive impairment.[10]

Scoring

MoCA scores range between 0 and 30.[11] A score of 26 or over is considered to be normal. In a study, people without cognitive impairment scored an average of 27.4; people with mild cognitive impairment (MCI) scored an average of 22.1; people with Alzheimer's disease scored an average of 16.2.[11]

In a study by Ihle-Hansen et al. (2017),[12] of 3,413 Norwegian participants aged 63-65, of whom 47% had higher education (>12 years), under 5% of subjects scored 30/30 with a mean MoCA score of 25.3 and 49% scoring below the suggested cut-off of 26 points, leading the authors to suggest that "the cut-off score may have been set too high to distinguish normal cognitive function from MCI".

Other applications

Since the MoCA assesses multiple cognitive domains, it can be a useful cognitive screening tool for several neurological diseases that affect younger populations, such as Parkinson's disease,[13][14][15] vascular cognitive impairment,[16][17] Huntington's disease,[18] brain metastasis, sleep behaviour disorder,[19] primary brain tumors (including high and low grade gliomas),[20] multiple sclerosis and other conditions such as traumatic brain injury, depression, schizophrenia and heart failure. The test is also used in hospitals to determine whether patients should be allowed to live alone or with a home aide.

See also

References
  1. Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (2005). "The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment". J Am Geriatr Soc. 53 (4): 695–9. doi:10.1111/j.1532-5415.2005.53221.x. PMID 15817019.
  2. Maust, Donovan; Cristancho, Mario; Gray, Laurie; Rushing, Susan; Tjoa, Chris; Thase, Michael E. (2012-01-01). Psychiatric rating scales. Handbook of Clinical Neurology. 106. pp. 227–237. doi:10.1016/B978-0-444-52002-9.00013-9. ISBN 9780444520029. ISSN 0072-9752. PMID 22608624.
  3. Borland, Emma; Nägga, Katarina; Nilsson, Peter M.; Minthon, Lennart; Nilsson, Erik D.; Palmqvist, Sebastian (2017-07-29). "The Montreal Cognitive Assessment: Normative Data from a Large Swedish Population-Based Cohort". Journal of Alzheimer's Disease. 59 (3): 893–901. doi:10.3233/JAD-170203. PMC 5545909. PMID 28697562.
  4. Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (2005). "The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment". J Am Geriatr Soc. 53 (4): 695–9. doi:10.1111/j.1532-5415.2005.53221.x. PMID 15817019.
  5. Dong, YanHong; Sharma, Vijay Kumar; Chan, Bernard Poon-Lap; Venketasubramanian, Narayanaswamy; Teoh, Hock Luen; Seet, Raymond Chee Seong; Tanicala, Sophia; Chan, Yiong Huak; Chen, Christopher (2010-12-15). "The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke". Journal of the Neurological Sciences. 299 (1–2): 15–18. doi:10.1016/j.jns.2010.08.051. ISSN 1878-5883. PMID 20889166.
  6. Pinto, Tiago C. C.; Machado, Leonardo; Bulgacov, Tatiana M.; Rodrigues-Júnior, Antônio L.; Costa, Maria L. G.; Ximenes, Rosana C. C.; Sougey, Everton B. (Apr 2019). "Is the Montreal Cognitive Assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer's Disease (AD) in the elderly?". International Psychogeriatrics. 31 (4): 491–504. doi:10.1017/S1041610218001370. ISSN 1741-203X. PMID 30426911.
  7. Fujiwara, Yoshinori; Suzuki, Hiroyuki; Yasunaga, Masashi; Sugiyama, Mika; Ijuin, Mutsuo; Sakuma, Naoko; Inagaki, Hiroki; Iwasa, Hajime; Ura, Chiaki (2010-07-01). "Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal Cognitive Assessment". Geriatrics & Gerontology International. 10 (3): 225–232. doi:10.1111/j.1447-0594.2010.00585.x. ISSN 1447-0594. PMID 20141536.
  8. Guo, Qi-Hao; Cao, Xin-Yi; Zhou, Yan; Zhao, Qian-Hua; Ding, Ding; Hong, Zhen (2010-02-01). "Application study of quick cognitive screening test in identifying mild cognitive impairment". Neuroscience Bulletin. 26 (1): 47–54. doi:10.1007/s12264-010-0816-4. ISSN 1995-8218. PMC 5560380. PMID 20101272.
  9. Luis, Cheryl A.; Keegan, Andrew P.; Mullan, Michael (2009-02-01). "Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the Southeastern US". International Journal of Geriatric Psychiatry. 24 (2): 197–201. doi:10.1002/gps.2101. ISSN 1099-1166. PMID 18850670.
  10. Hachinski, Vladimir; Iadecola, Costantino; Petersen, Ron C.; Breteler, Monique M.; Nyenhuis, David L.; Black, Sandra E.; Powers, William J.; DeCarli, Charles; Merino, Jose G. (2006-09-01). "National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards". Stroke: A Journal of Cerebral Circulation. 37 (9): 2220–2241. doi:10.1161/01.STR.0000237236.88823.47. ISSN 1524-4628. PMID 16917086.
  11. "Montreal Cognitive Assessment (MoCA) Test: Scoring & Accuracy". Verywell. Retrieved 12 June 2017.
  12. Ihle-Hansen, H.; Vigen, T.; Berge, T.; Einvik, G.; Aarsland, D.; Rønning, O.M.; Thommessen, B.; Røsjø, H.; Tveit, A. (2017). "Montreal Cognitive Assessment in a 63- to 65-year-old Norwegian Cohort from the General Population: Data from the Akershus Cardiac Examination 1950 Study". Dementia and Geriatric Cognitive Disorders Extra. 7 (3): 318–327. ISSN 1664-5464.
  13. Dalrymple-Alford, J. C.; MacAskill, M. R.; Nakas, C. T.; Livingston, L.; Graham, C.; Crucian, G. P.; Melzer, T. R.; Kirwan, J.; Keenan, R. (2010-11-09). "The MoCA: well-suited screen for cognitive impairment in Parkinson disease". Neurology. 75 (19): 1717–1725. doi:10.1212/WNL.0b013e3181fc29c9. ISSN 1526-632X. PMID 21060094.
  14. Kasten, Meike; Bruggemann, Norbert; Schmidt, Alexander; Klein, Christine (2010-08-03). "Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease". Neurology. 75 (5): 478–479. doi:10.1212/WNL.0b013e3181e7948a. ISSN 0028-3878. PMC 2788810. PMID 20679642.
  15. Hoops, S; Nazem, S; Siderowf, A D.; Duda, J E.; Xie, S X.; Stern, M B.; Weintraub, D (2009-11-24). "Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease". Neurology. 73 (21): 1738–1745. doi:10.1212/WNL.0b013e3181c34b47. ISSN 0028-3878. PMC 2788810. PMID 19933974.
  16. Cameron, Jan; Worrall-Carter, Linda; Page, Karen; Riegel, Barbara; Lo, Sing Kai; Stewart, Simon (2010-05-01). "Does cognitive impairment predict poor self-care in patients with heart failure?". European Journal of Heart Failure. 12 (5): 508–515. doi:10.1093/eurjhf/hfq042. ISSN 1879-0844. PMID 20354031.
  17. Wong, Adrian; Xiong, Yun Y.; Kwan, Pauline W. L.; Chan, Anne Y. Y.; Lam, Wynnie W. M.; Wang, Ki; Chu, Winnie C. W.; Nyenhuis, David L.; Nasreddine, Ziad (2009-01-01). "The validity, reliability and clinical utility of the Hong Kong Montreal Cognitive Assessment (HK-MoCA) in patients with cerebral small vessel disease". Dementia and Geriatric Cognitive Disorders. 28 (1): 81–87. doi:10.1159/000232589. ISSN 1421-9824. PMID 19672065.
  18. Videnovic, Aleksandar; Bernard, Bryan; Fan, Wenqing; Jaglin, Jeana; Leurgans, Sue; Shannon, Kathleen M. (2010-02-15). "The Montreal Cognitive Assessment as a screening tool for cognitive dysfunction in Huntington's disease". Movement Disorders. 25 (3): 401–404. doi:10.1002/mds.22748. ISSN 1531-8257. PMID 20108371.
  19. Bertrand, Josie-Anne; Marchand, Daphné Génier; Postuma, Ronald B.; Gagnon, Jean-François (2016-07-28). "Cognitive dysfunction in rapid eye movement sleep behavior disorder". Sleep and Biological Rhythms. 11 (1): 21–26. doi:10.1111/j.1479-8425.2012.00547.x. ISSN 1446-9235.
  20. Olson, Robert Anton; Chhanabhai, Taruna; McKenzie, Michael (2008-11-01). "Feasibility study of the Montreal Cognitive Assessment (MoCA) in patients with brain metastases". Supportive Care in Cancer. 16 (11): 1273–1278. doi:10.1007/s00520-008-0431-3. ISSN 0941-4355. PMID 18335256.
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