Myocardin

Myocardin is a protein that in humans is encoded by the MYOCD gene.[5][6][7]

MYOCD
Identifiers
AliasesMYOCD, MYCD, myocardin, MGBL
External IDsOMIM: 606127 MGI: 2137495 HomoloGene: 17043 GeneCards: MYOCD
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p12Start12,665,890 bp[1]
End12,768,949 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

93649

214384

Ensembl

ENSG00000141052

ENSMUSG00000020542

UniProt

Q8IZQ8

Q8VIM5

RefSeq (mRNA)

NM_001146312
NM_001146313
NM_153604
NM_001378306

NM_145136
NM_146386

RefSeq (protein)

NP_001139784
NP_705832
NP_001365235

NP_660118
NP_666498

Location (UCSC)Chr 17: 12.67 – 12.77 MbChr 11: 65.18 – 65.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myocardin is a smooth muscle and cardiac muscle-specific transcriptional coactivator of serum response factor. When expressed ectopically in nonmuscle cells, myocardin can induce smooth muscle differentiation by its association with serum response factor (SRF; MIM 600589).[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000141052 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020542 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E, Krieg PA, Olson EN (Jul 2001). "Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor". Cell. 105 (7): 851–62. doi:10.1016/S0092-8674(01)00404-4. PMID 11439182. S2CID 3762021.
  6. Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN (Nov 2002). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors". Proc Natl Acad Sci U S A. 99 (23): 14855–60. doi:10.1073/pnas.222561499. PMC 137508. PMID 12397177.
  7. "Entrez Gene: MYOCD myocardin".

Further reading


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