NRON

ncRNA Repressor of NFAT (nuclear factor of activated T cells)
	Predicted secondary structure and sequence conservation of NRON
Identifiers
Symbol	NRON
Rfam	RF00636
Other data
RNA type	Gene
Domain(s)	Eukaryota
SO	SO:0001263
PDB structures	PDBe

NRON also known as ncRNA repressor of the nuclear factor of activated T cells is a non-coding RNA involved in repressing NFAT.[1] The function of this ncRNA was identified by a large-scale screen of 512 non-coding RNAs discovered in earlier EST sequencing projects.[2][3]

Each of the RNAs that were conserved between human and mouse were knocked down using shRNAs. The resulting cell-lines were screened for changes in activity of NFAT.

References

Willingham AT, Orth AP, Batalov S, Peters EC, Wen BG, Aza-Blanc P, Hogenesch JB, Schultz PG (September 2005). "A strategy for probing the function of noncoding RNAs finds a repressor of NFAT". Science. 309 (5740): 1570–1573. doi:10.1126/science.1115901. PMID 16141075.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, et al. (December 2002). "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs" (PDF). Nature. 420 (6915): 563–573. doi:10.1038/nature01266. PMID 12466851.
Numata K, Kanai A, Saito R, Kondo S, Adachi J, Wilming LG, Hume DA, Hayashizaki Y, Tomita M (June 2003). "Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection". Genome Research. 13 (6B): 1301–1306. doi:10.1101/gr.1011603. PMC 403720. PMID 12819127.

External links

Page for NRON at Rfam

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[pmid16141075-1] Willingham AT, Orth AP, Batalov S, Peters EC, Wen BG, Aza-Blanc P, Hogenesch JB, Schultz PG (September 2005). "A strategy for probing the function of noncoding RNAs finds a repressor of NFAT". Science. 309 (5740): 1570–1573. doi:10.1126/science.1115901. PMID 16141075.

[pmid12466851-2] Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, et al. (December 2002). "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs" (PDF). Nature. 420 (6915): 563–573. doi:10.1038/nature01266. PMID 12466851.

[pmid12819127-3] Numata K, Kanai A, Saito R, Kondo S, Adachi J, Wilming LG, Hume DA, Hayashizaki Y, Tomita M (June 2003). "Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection". Genome Research. 13 (6B): 1301–1306. doi:10.1101/gr.1011603. PMC 403720. PMID 12819127.