NXPH1

Neurexophilin-1 is a protein that in humans is encoded by the NXPH1 gene.[5][6]

NXPH1
Identifiers
AliasesNXPH1, NPH1, Nbla00697, neurexophilin 1
External IDsOMIM: 604639 MGI: 107492 HomoloGene: 8284 GeneCards: NXPH1
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p21.3Start8,433,609 bp[1]
End8,752,961 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

30010

18231

Ensembl

ENSG00000122584

ENSMUSG00000046178

UniProt

P58417

Q61200

RefSeq (mRNA)

NM_152745

NM_008751

RefSeq (protein)

NP_689958

NP_032777

Location (UCSC)Chr 7: 8.43 – 8.75 MbChr 6: 8.95 – 9.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000122584 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000046178 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Missler M, Sudhof TC (Jun 1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins". J Neurosci. 18 (10): 3630–8. doi:10.1523/JNEUROSCI.18-10-03630.1998. PMC 6793134. PMID 9570794.
  6. "Entrez Gene: NXPH1 neurexophilin 1".

Further reading


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