New York State Route 80

NY 80 begins at an intersection with NY 175 in southern Syracuse. The route, named Valley Drive, proceeds south through a largely residential area of Syracuse, following the path of Onondaga Creek through the area. 1 mile (1.6 km) to the south of NY 175 (and 1 mile (1.6 km) west of the interchange between Interstate 81 and Interstate 481), NY 80 intersects NY 173 (the old path of the Seneca Turnpike) near the southern city limits, which erroneously shows it as NY 80's western terminus in the 2017 route log.[4] Past NY 173, NY 80 parallels U.S. Route 11, I-81, and Onondaga Creek as all four head south out of Syracuse. At the city line, NY 80 becomes South Onondaga Road.

NY 11A's southern terminus at NY 80 in Tully

In Onondaga, south of Syracuse, NY 80 briefly enters the Onondaga Nation Territory, cutting across the northwestern corner of the reservation before turning to follow the western edge of the territory. NY 80 leaves to the southwest shortly after to serve South Onondaga and intersect U.S. Route 20 at Lords Corners. Past US 20, NY 80 continues south to Otisco (coming within 3 miles (5 km) of Otisco Lake), then curves southeast to the Tully hamlet of Vesper before turning fully to the east as it enters the village of Tully.

NY 80 at I-81, US 11 and NY 281 in Onondaga County

Just west of Tully, NY 80 intersects NY 11A, US 11, and NY 281 on opposite sides of an overpass carrying I-81 over NY 80. Here, all three routes, plus County Route 134 (CR 134) to the southwest, act as frontage roads for I-81 exit 14. US 11 joins NY 80 east of the interchange, following the route into Tully. US 11 heads south at the village center; NY 80, however, continues eastward, overlapping NY 91 near Fabius and NY 13 in western Madison County. Past NY 13, NY 80 continues southeast to Georgetown, where it meets NY 26. The two routes conjoin and head south into Chenango County before separating shortly after crossing the county line. Within Chenango County, NY 80 largely follows an east–west routing with a slight curve to the southeast. Incorporated municipalities 80 passes through within Chenango County include Smyrna, Sherburne, and New Berlin. East of Smyrna, NY 80 continues east, then curves to the southeast as it approaches the Otsego County line, delimited by the Unadilla River.

After crossing over the Chenango River and into Sherburne, NY 80 intersects NY 12 and begins to follow the old path of the Second Great Western Turnpike across Central New York. The route continues east to Columbus, where NY 80 separates from the old routing of the turnpike, at an intersection with CR 25. From Columbus NY 80 heads southeast to intersect NY 8 north of New Berlin. NY 80 turns south onto NY 8, overlapping the route to New Berlin, where the routes split at the village center. Outside of New Berlin, NY 80 heads northeast to Edmeston, where it rejoins the routing of the Second Great Western Turnpike at an intersection with CR 20. From Edmeston NY 80 heads east to intersect NY 51 in West Burlington, creating a brief, 1-mile (1.6 km) long concurrency between the two routes. Soon after NY 51 splits off NY 80 and continues north toward West Winfield.

West end of NY 80 and NY 28 overlap at NY 205

NY 80 heads due east from NY 51 to Otsego, where it meets NY 205. NY 205 joins NY 80 eastward into a small valley surrounding Oaks Creek, where the two routes meet NY 28. While NY 205 terminates here, NY 80 joins NY 28, following the route east across the creek and through the hamlet of Fly Creek.

To the east of Fly Creek, NY 28 and NY 80 ascend in elevation for a short distance prior to descending into a valley home to both the southern tip of Otsego Lake and the historic village of Cooperstown at its tip. Shortly after entering Cooperstown, the two routes split as NY 28 turns south at Chestnut Street, following the roadway out of the village toward Oneonta. NY 80, however, turns north onto Chestnut and continues into the heart of the village, where it intersects Main Street, a street lined with shops catering to tourists who visit the nearby National Baseball Hall of Fame. At this intersection, the Second Great Western Turnpike turned east; however, NY 80 continues north on Chestnut for another block before turning onto Lake Street and following the street out of the village.

NY 80 and US 20 shields

Outside of Cooperstown, NY 80 heads north along the western edge of Otsego Lake, passing by both the Fenimore Art Museum and the Farmers' Museum just north of Cooperstown, as well as the Glimmerglass Opera further up the road. Near the northern tip of the lake in Springfield, NY 80 intersects US 20 (the former Cherry Valley Turnpike) for the second time, where it becomes signed as a north-south route. The route continues northward, although the progression becomes more northeasterly as it crosses into the rural southeastern corner of Herkimer County. NY 80's stay within the county is brief, passing through the hamlet of Van Hornesville, home of the Owen D. Young Central School, established by noted American industrialist Owen D. Young. Young also founded RCA (the Radio Corporation of America). The route features no additional points of interest other than an intersection with NY 168 located at the midpoint between where NY 80 traverses the Otsego and Montgomery County lines.

Upon entering Montgomery County, NY 80 heads east to Fort Plain, a village located on the Mohawk River (here serving as the path of the Erie Canal), and becomes Main Street. At Kellogg Street, NY 80 is joined by NY 163 for two blocks to an intersection with NY 5S (Canal Street) in the heart of the village, although NY 163 is signed as ending at NY 80. Here, NY 163 ends while NY 5S and NY 80 come together on Main Street for a short overlap to Hancock Street, where NY 5S turns southeast and continues toward Canajoharie. NY 80, however, continues through and out of the village to the northeast on Main, Willett, and River Streets. Once on River, NY 80 passes under the New York State Thruway (Interstate 90) and crosses the Mohawk River before terminating at NY 5 on the opposite bank in Nelliston.