Nucleoporin 133

Nucleoporin 133 (Nup133) is a protein that in humans is encoded by the NUP133 gene.[5][6]

NUP133
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUP133, hnucleoporin 133kDa, nucleoporin 133, NPHS18, GAMOS8
External IDsOMIM: 607613 MGI: 2442620 HomoloGene: 32402 GeneCards: NUP133
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q42.13Start229,440,259 bp[1]
End229,508,341 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55746

234865

Ensembl

ENSG00000069248

ENSMUSG00000039509

UniProt

Q8WUM0

Q8R0G9

RefSeq (mRNA)

NM_018230

NM_172288

RefSeq (protein)

NP_060700

NP_758492

Location (UCSC)Chr 1: 229.44 – 229.51 MbChr 8: 123.9 – 123.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells.[6]

Interactions

Nup133 has been shown to interact with NUP107.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000069248 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000039509 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ (Oct 2001). "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export". The Journal of Cell Biology. 155 (3): 339–54. doi:10.1083/jcb.200108007. PMC 2150853. PMID 11684705.
  6. "Entrez Gene: NUP133 nucleoporin 133kDa".
  7. Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
  8. Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.