ODC1

ODC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OO0, 4ZGY, 5BWA, 1D7K, 2ON3
Identifiers
Aliases	ODC1, ODC, ornithine decarboxylase 1
External IDs	OMIM: 165640 MGI: 97402 HomoloGene: 1906 GeneCards: ODC1
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	10,448,327 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	17,551,505 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• ornithine decarboxylase activity; • GO:0001948 protein binding; • protein homodimerization activity; • carboxy-lyase activity; • catalytic activity; • lyase activity;
Cellular component	• perinuclear region of cytoplasm; • cytosol; • cytoplasm; • cellular component;
Biological process	• putrescine biosynthetic process; • polyamine biosynthetic process; • response to virus; • polyamine metabolic process; • regulation of cellular amino acid metabolic process; • positive regulation of cell proliferation; • kidney development; • regulation of protein catabolic process; • putrescine biosynthetic process from ornithine;
	Sources:Amigo / QuickGO
Orthologs
	4953
	18263
	ENSG00000115758
	ENSMUSG00000011179
	P11926
	P00860
	NM_002539; NM_001287188; NM_001287189; NM_001287190
	NM_013614
	NP_001274117; NP_001274118; NP_001274119; NP_002530
	NP_038642
	Wikidata
View/Edit Human	View/Edit Mouse

Ornithine decarboxylase is an enzyme that in humans is encoded by the ODC1 gene.

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.[5]

References

GRCh38: Ensembl release 89: ENSG00000115758 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000011179 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ODC1 ornithine decarboxylase 1".

Pegg AE (May 2006). "Regulation of ornithine decarboxylase". The Journal of Biological Chemistry. 281 (21): 14529–32. doi:10.1074/jbc.R500031200. PMID 16459331.
Yoshida M, Hayashi H, Taira M, Isono K (December 1992). "Elevated expression of the ornithine decarboxylase gene in human esophageal cancer". Cancer Research. 52 (23): 6671–5. PMID 1423312.
Moshier JA, Osborne DL, Skunca M, Dosescu J, Gilbert JD, Fitzgerald MC, et al. (May 1992). "Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells". Nucleic Acids Research. 20 (10): 2581–90. doi:10.1093/nar/20.10.2581. PMC 312396. PMID 1598217.
Hickok NJ, Wahlfors J, Crozat A, Halmekytö M, Alhonen L, Jänne J, Jänne OA (September 1990). "Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene". Gene. 93 (2): 257–63. doi:10.1016/0378-1119(90)90233-H. PMID 2227439.
Hsieh JT, Denning MF, Heidel SM, Verma AK (April 1990). "Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells". Cancer Research. 50 (8): 2239–44. PMID 2317811.
Moshier JA, Gilbert JD, Skunca M, Dosescu J, Almodovar KM, Luk GD (March 1990). "Isolation and expression of a human ornithine decarboxylase gene". The Journal of Biological Chemistry. 265 (9): 4884–92. PMID 2318872.
Verrando P, Juhlin L, Lacour JP, Ortonne JP (April 1987). "Immunohistochemical localization of ornithine decarboxylase in human skin". The Journal of Dermatology. 14 (2): 112–7. doi:10.1111/j.1346-8138.1987.tb03542.x. PMID 2440930. S2CID 39626267.
van Steeg H, van Oostrom CT, Martens JW, van Kreyl C, Schepens J, Wieringa B (November 1989). "Nucleotide sequence of the human ornithine decarboxylase gene". Nucleic Acids Research. 17 (21): 8855–6. doi:10.1093/nar/17.21.8855. PMC 335049. PMID 2587220.
Fitzgerald MC, Flanagan MA (November 1989). "Characterization and sequence analysis of the human ornithine decarboxylase gene". Dna. 8 (9): 623–34. doi:10.1089/dna.1.1989.8.623. PMID 2693021.
Alhonen-Hongisto L, Leinonen P, Sinervirta R, Laine R, Winqvist R, Alitalo K, et al. (February 1987). "Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification". The Biochemical Journal. 242 (1): 205–10. doi:10.1042/bj2420205. PMC 1147684. PMID 3036086.
Kaczmarek L, Calabretta B, Ferrari S, de Riel JK (September 1987). "Cell-cycle-dependent expression of human ornithine decarboxylase". Journal of Cellular Physiology. 132 (3): 545–51. doi:10.1002/jcp.1041320318. PMID 3308908. S2CID 45689962.
Hickok NJ, Seppänen PJ, Gunsalus GL, Jänne OA (June 1987). "Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA". Dna. 6 (3): 179–87. doi:10.1089/dna.1987.6.179. PMID 3595418.
Winqvist R, Mäkelä TP, Seppänen P, Jänne OA, Alhonen-Hongisto L, Jänne J, et al. (1986). "Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene". Cytogenetics and Cell Genetics. 42 (3): 133–40. doi:10.1159/000132266. PMID 3755388.
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, et al. (December 1994). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Kim YJ, Pan H, Verma AK (July 1994). "Non-AP-1 tumor promoter 12-O-tetradecanoylphorbol-13-acetate-responsive sequences in the human ornithine decarboxylase gene". Molecular Carcinogenesis. 10 (3): 169–79. doi:10.1002/mc.2940100308. PMID 8043198. S2CID 12159876.
Müller M, Pajunen AE, Järvinen M, Poeggel G, Bernstein HG (1994). "Immunohistochemical demonstration of L-ornithine decarboxylase enzyme protein in different areas of the developing human brain". Developmental Neuroscience. 15 (2): 87–93. doi:10.1159/000111320. PMID 8168440.
Ichiba T, Matsufuji S, Miyazaki Y, Murakami Y, Tanaka K, Ichihara A, Hayashi S (May 1994). "Functional regions of ornithine decarboxylase antizyme". Biochemical and Biophysical Research Communications. 200 (3): 1721–7. doi:10.1006/bbrc.1994.1651. PMID 8185631.
Wright PS, Cooper JR, Cross-Doersen DE, Miller JA, Chmielewski PA, Wagner RL, et al. (September 1995). "Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element". Cell Growth & Differentiation. 6 (9): 1097–102. PMID 8519686.
Heiskala M, Zhang J, Hayashi S, Hölttä E, Andersson LC (March 1999). "Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation". The EMBO Journal. 18 (5): 1214–22. doi:10.1093/emboj/18.5.1214. PMC 1171212. PMID 10064588.
Pomidor MM, Cimildoro R, Lazatin B, Zheng P, Gurr JA, Leigh IM, et al. (December 1999). "Phosphorylated human keratinocyte ornithine decarboxylase is preferentially associated with insoluble cellular proteins". Molecular Biology of the Cell. 10 (12): 4299–310. doi:10.1091/mbc.10.12.4299. PMC 25759. PMID 10588659.
Symes AJ, Eilertsen M, Millar M, Nariculam J, Freeman A, Notara M, et al. (2013). "Quantitative analysis of BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue". PLOS One. 8 (12): e84295. doi:10.1371/journal.pone.0084295. PMC 3874000. PMID 24386364.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115758 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000011179 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ODC1 ornithine decarboxylase 1".

ODC1

References

Further reading