OSCAR (gene)

Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene.[5][6]

OSCAR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOSCAR, PIGR3, PIgR-3, osteoclast associated, immunoglobulin-like receptor, osteoclast associated Ig-like receptor
External IDsOMIM: 606862 MGI: 2179720 HomoloGene: 77042 GeneCards: OSCAR
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.42Start54,094,668 bp[1]
End54,102,692 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

126014

232790

Ensembl

ENSMUSG00000054594

UniProt

Q8IYS5

Q8VBT3

RefSeq (mRNA)

NM_001290377
NM_175632

RefSeq (protein)

NP_001277306
NP_783440

Location (UCSC)Chr 19: 54.09 – 54.1 MbChr 7: 3.61 – 3.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[6]

References

Further reading


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