OSR2 (gene)

Protein odd-skipped-related 2 is a protein that in humans is encoded by the OSR2 gene.[5] In mice, it is involved in the development of the palate and in suppressing the formation of teeth after the eruption of adult teeth.

OSR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EE8
Identifiers
Aliases	OSR2, odd-skipped related transciption factor 2
External IDs	OMIM: 611297 MGI: 1930813 HomoloGene: 14200 GeneCards: OSR2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.2 Start 98,944,403 bp[1] End 98,952,104 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 14.46 cM Start 35,296,098 bp[2] End 35,303,305 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • GO:0001948 protein binding • nucleic acid binding • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II regulatory region sequence-specific DNA binding Cellular component • cell nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • metanephros development • mesonephros development • chondrocyte differentiation • positive regulation of cell proliferation • positive regulation of gene expression • cell differentiation • positive regulation of bone mineralization • osteoblast proliferation • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • embryonic skeletal limb joint morphogenesis • middle ear morphogenesis • odontogenesis • embryonic digit morphogenesis • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • embryonic skeletal system morphogenesis • positive regulation of epithelial cell proliferation • palate development • embryonic skeletal joint morphogenesis • head development • bone morphogenesis • eyelid development in camera-type eye • embryonic skeletal joint development • embryo development ending in birth or egg hatching • urogenital system development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116039	107587
Ensembl	ENSG00000164920	ENSMUSG00000022330
UniProt	Q8N2R0	Q91ZD1
RefSeq (mRNA)	NM_001142462 NM_001286841 NM_053001	NM_054049 NM_001368665
RefSeq (protein)	NP_001135934 NP_001273770 NP_443727	NP_473390 NP_001355594
Location (UCSC)	Chr 8: 98.94 – 98.95 Mb	Chr 15: 35.3 – 35.3 Mb
PubMed search	[3]	[4]
Wikidata
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