Orotate reductase (NADPH)
In enzymology, an orotate reductase (NADPH) (EC 1.3.1.15) is an enzyme that catalyzes the chemical reaction
- (S)-dihydroorotate + NADP+ orotate + NADPH + H+
| orotate reductase (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.15 | ||||||||
| CAS number | 37255-27-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are (S)-dihydroorotate and NADP+, whereas its 3 products are orotate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NADP+ oxidoreductase. Other names in common use include orotate reductase, dihydroorotate dehydrogenase, dihydro-orotic dehydrogenase, L-5,6-dihydro-orotate:NAD+ oxidoreductase, and orotate reductase (NADPH). It has one cofactor, FAD.
References
- Taylor WH, Taylor ML, Eames DF (1966). "Two functionally different dihydroorotic dehydrogenases in bacteria". J. Bacteriol. 91 (6): 2251–6. PMC 316202. PMID 4380263.
- Ukada S, Vennesland B (1962). "Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase". J. Biol. Chem. 237: 2018–2024. PMID 13923427.
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