P24 protein family
P24 protein family is a group of transmembrane proteins that are major components of COPI and COPII-coated vesicles. The family is also known as EMP24/GP25L/p24 family and TMP21-like proteins. The latter naming was after transmembrane emp24 domain-containing protein 10 that was found in the human brain. It was claimed to block the beta-amyloid peptide, which is implicated in the pathogenesis of Alzheimer's Disease.
| P24 protein family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TMP21 | ||||||||
| Pfam | PF01105 | ||||||||
| InterPro | IPR015720 | ||||||||
| Membranome | 140 | ||||||||
| |||||||||
References
Further reading
- "Protein blocks Alzheimer's toxins in lab tests". CBC News. 27 April 2006.
- Chien F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, et al. (2006). "TMP21 is a presenilin complex component that modulates gamma-but not epsilon-secretase activities". Nature. 440: 1208–1212.
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