PAFAH2

Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene.[5][6][7] It is one of several PAF acetylhydrolases.

PAFAH2
Identifiers
AliasesPAFAH2, HSD-PLA2, platelet activating factor acetylhydrolase 2
External IDsOMIM: 602344 MGI: 2140321 HomoloGene: 37309 GeneCards: PAFAH2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.11Start25,959,767 bp[1]
End25,998,117 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5051

100163

Ensembl

ENSG00000158006

ENSMUSG00000037366

UniProt

Q99487
Q5SY00

Q8VDG7

RefSeq (mRNA)

NM_000437

NM_001285872
NM_001285874
NM_001285875
NM_001285877
NM_133880

RefSeq (protein)

NP_000428

NP_001272801
NP_001272803
NP_001272804
NP_001272806
NP_598641

Location (UCSC)Chr 1: 25.96 – 26 MbChr 4: 134.4 – 134.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000158006 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037366 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hattori K, Adachi H, Matsuzawa A, Yamamoto K, Tsujimoto M, Aoki J, Hattori M, Arai H, Inoue K (Dec 1996). "cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase". The Journal of Biological Chemistry. 271 (51): 33032–8. doi:10.1074/jbc.271.51.33032. PMID 8955149.
  6. Rice SQ, Southan C, Boyd HF, Terrett JA, MacPhee CH, Moores K, Gloger IS, Tew DG (Mar 1998). "Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor". The Biochemical Journal. 330 ( Pt 3) (3): 1309–15. doi:10.1042/bj3301309. PMC 1219277. PMID 9494101.
  7. "Entrez Gene: PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa".

Further reading


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